{"id":"27a0bfeb8d8e","type":"article","url":"https://hartvaat.nl/2022/06/01/vijf-jaar-inspanningstraining-verbetert-cardiovasculair-risicoprofiel-bij-oudere/","title":"Vijf jaar inspanningstraining verbetert cardiovasculair risicoprofiel bij ouderen","title_en":"Effect of 5 years of exercise training on the cardiovascular risk profile of older adults: the Generation 100 randomized trial.","category":"atriumfibrilleren","category_label":"Atriumfibrilleren","professions":["cardioloog","huisarts"],"tags":["acuut-hartfalen","atleten","biomarkers-cardiovasculair","bloeddrukbehandeling","bradycardie","diabetes-en-hart","diabetes-type-2","farmaco-economie","fractional-flow-reserve","hartrevalidatie","lichaamsbeweging","obesitas","ouderen","perifeer-vaatlijden","richtlijnen-esc","roken","secundaire-preventie","slaapapneu","summit-trial","supraventriculaire-tachycardie","ventrikelfibrilleren"],"journal":"European heart journal","doi":"10.1093/eurheartj/ehab721","source_url":"https://doi.org/10.1093/eurheartj/ehab721","authors":["Jon Magne Letnes","Ida Berglund","Kristin E Johnson","Håvard Dalen","Bjarne M Nes","Stian Lydersen","Hallgeir Viken","Erlend Hassel","Sigurd Steinshamn","Elisabeth Kleivhaug Vesterbekkmo","Asbjørn Støylen","Line S Reitlo","Nina Zisko","Fredrik H Bækkerud","Atefe R Tari","Jan Erik Ingebrigtsen","Silvana B Sandbakk","Trude Carlsen","Sigmund A Anderssen","Maria A Fiatarone Singh","Jeff S Coombes","Jorunn L Helbostad","Øivind Rognmo","Ulrik Wisløff","Dorthe Stensvold"],"significance":7,"published":"2022-06-01","source_date":"2022-06-01","image":"","kennis":["https://hartvaat.nl/kennis/atriumfibrilleren/af-bij-ouderen/"],"congress":"","summary_en":"The Generation 100 trial showed that 5 years of supervised exercise training in adults aged 70-77 improved several cardiovascular risk factors including blood pressure, lipids, and body composition, demonstrating the sustained cardiovascular benefit of structured exercise in the elderly.","created":"2026-07-03T10:29:47Z","updated":"2026-07-03T18:38:52Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"De Generation 100-trial toonde dat 5 jaar gestructureerde inspanningstraining bij 70-77-jarigen het cardiovasculaire risicoprofiel verbeterde, met significante afname van bloeddruk, rustpols en lichaamsvet. Hoog-intensieve intervaltraining (HIIT) gaf de grootste verbeteringen.","abstract_original":"AIMS: The aim of this study was to compare the effects of 5 years of supervised exercise training (ExComb), and the differential effects of subgroups of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT), with control on the cardiovascular risk profile in older adults. METHODS AND RESULTS: Older adults aged 70-77 years from Trondheim, Norway (n = 1567, 50% women), able to safely perform exercise training were randomized to 5 years of two weekly sessions of HIIT [∼90% of peak heart rate (HR), n = 400] or MICT (∼70% of peak HR, n = 387), together forming ExComb (n = 787), or control (instructed to follow physical activity recommendations, n = 780). The main outcome was a continuous cardiovascular risk score (CCR), individual cardiovascular risk factors, and peak oxygen uptake (VO2peak). CCR was not significantly lower [-0.19, 99% confidence interval (CI) -0.46 to 0.07] and VO2peak was not significantly higher (0.39 mL/kg/min, 99% CI -0.22 to 1.00) for ExComb vs. control. HIIT showed higher VO2peak (0.76 mL/kg/min, 99% CI 0.02-1.51), but not lower CCR (-0.32, 99% CI -0.64 to 0.01) vs. control. MICT did not show significant differences compared to control or HIIT. Individual risk factors mostly did not show significant between-group differences, with some exceptions for HIIT being better than control. There was no significant effect modification by sex. The number of cardiovascular events was similar across groups. The healthy and fit study sample, and contamination and cross-over between intervention groups, challenged the possibility of detecting between-group differences. CONCLUSIONS: Five years of supervised exercise training in older adults had little effect on cardiovascular risk profile and did not reduce cardiovascular events. REGISTRATION: ClinicalTrials.gov: NCT01666340."}