# Atriumfibrilleren na transcatheter ASD-sluiting: systematische review

*geplaatst 2022-07-13 · Atriumfibrilleren · Heart (British Cardiac Society) · doi 10.1136/heartjnl-2021-319794 · https://hartvaat.nl/2022/07/13/atriumfibrilleren-na-transcatheter-asd-sluiting-systematische-review/*

Meta-analyse toonde dat nieuw-ontstaan atriumfibrilleren een relevante complicatie is na transcatheter sluiting van atriumseptumdefecten. De incidentie was significant, vooral bij oudere patiënten en grotere defecten. Langdurige monitoring na sluiting wordt aanbevolen.

## English: Atrial fibrillation following transcatheter atrial septal defect closure: a systematic review and meta-analysis.

This meta-analysis showed that new-onset AF is a relevant complication after transcatheter closure of atrial septal defects, informing the follow-up monitoring and anticoagulation considerations after ASD device closure.

## Abstract (original, from the publication)

OBJECTIVE: The ostium secundum atrial septal defect (ASD) is among the most common congenital cardiac anomalies diagnosed in adulthood. A known complication of transcatheter ASD closure is the development of new-onset atrial fibrillation and flutter (AFi/AFl). These arrhythmias confer an increased risk of postoperative stroke, thrombus formation and systemic emboli. This systematic review examines the burden of de novo AFi/AFl in adults following transcatheter closure and seeks to identify risk factors for AFi/AFl development. METHODS: Studies were identified by a search of MEDLINE, EMBASE and Cochrane databases from inception until 29 April 2020. A meta-analysis of AFi/AFl incidence was performed using a random-effects model. RESULTS: A total of 31 studies met inclusion criteria, comprising 4788 adult patients without a history of AFi/AFl. Twenty-three studies were included in quantitative synthesis and demonstrated an overall incidence rate of 1.82 patients per 100 person-years of follow-up (I2=83%). In studies that enrolled only patients ≥60 years old, the incidence was 5.21 patients per 100 person-years (I2=0%). Studies with follow-up duration ≤2 years reported an incidence of 4.05 per 100 person-years (I2=55%) compared with a rate of 1.19 per 100 person-years (I2=85%) for studies with follow-up duration >2 years. CONCLUSIONS: The incidence of new-onset AFi/AFl is relatively low following transcatheter closure of secundum ASDs. The rate of de novo AFi/AFl, however, was significantly higher in elderly patients. Shorter follow-up time was associated with a higher reported incidence of AFi/AFl.

Auteurs: Jonah Daniel Himelfarb, Healey Shulman, Christopher James Olesovsky, Rawan K Rumman, Laura Oliva, Joshua Friedland, Ashley Farrell, Ella Huszti, Eric Horlick, Lusine Abrahamyan

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Bron: Heart (British Cardiac Society), https://doi.org/10.1136/heartjnl-2021-319794. Bijgewerkt 2026-07-03T18:38:53Z. Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.