{"id":"e5f0738341d6","type":"article","url":"https://hartvaat.nl/2022/08/30/ripcord-2-routinematige-ffr-meting-versus-conventionele-angiografie/","title":"RIPCORD 2: routinematige FFR-meting versus conventionele angiografie","title_en":"Routine Pressure Wire Assessment Versus Conventional Angiography in the Management of Patients With Coronary Artery Disease: The RIPCORD 2 Trial.","category":"algemeen","category_label":"Algemeen","professions":["cardioloog"],"tags":[],"journal":"Circulation","doi":"10.1161/CIRCULATIONAHA.121.057793","source_url":"https://doi.org/10.1161/CIRCULATIONAHA.121.057793","authors":["Rodney H Stables","Liam J Mullen","Mostafa Elguindy","Zoe Nicholas","Yousra H Aboul-Enien","Ian Kemp","Peter O'Kane","Alex Hobson","Thomas W Johnson","Sohail Q Khan","Stephen B Wheatcroft","Scot Garg","Azfar G Zaman","Mamas A Mamas","James Nolan","Sachin Jadhav","Colin Berry","Stuart Watkins","David Hildick-Smith","Julian Gunn","Dwayne Conway","Angels Hoye","Iftikhar A Fazal","Colm G Hanratty","Bernard De Bruyne","Nick Curzen"],"significance":7,"published":"2022-08-30","source_date":"2022-08-30","image":"","kennis":["https://hartvaat.nl/kennis/coronairlijden/coronaire-angiografie-hartkatheterisatie/","https://hartvaat.nl/kennis/antistolling/doacs-overzicht/"],"congress":"","summary_en":"The RIPCORD 2 trial showed that routine FFR measurement during diagnostic coronary angiography frequently changes the management plan but does not improve clinical outcomes compared with conventional angiography-guided decision-making.","created":"2026-07-03T10:29:54Z","updated":"2026-07-03T13:29:00Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"De RIPCORD 2-trial toonde dat routinematige FFR-meting bij diagnostische coronairangiografie het behandelplan veranderde maar niet leidde tot betere klinische uitkomsten na 1 jaar vergeleken met conventionele angiografie. Selectief FFR-gebruik blijft de standaard.","abstract_original":"BACKGROUND: Measurement of fractional flow reserve (FFR) has an established role in guiding percutaneous coronary intervention. We tested the hypothesis that, at the stage of diagnostic invasive coronary angiography, systematic FFR-guided assessment of coronary artery disease would be superior, in terms of resource use and quality of life, to assessment by angiography alone. METHODS: We performed an open-label, randomized, controlled trial in 17 UK centers, recruiting 1100 patients undergoing invasive coronary angiography for the investigation of stable angina or non-ST-segment-elevation myocardial infarction. Patients were randomized to either angiography alone (angiography) or angiography with systematic pressure wire assessment of all epicardial vessels >2.25 mm in diameter (angiography+FFR). The coprimary outcomes assessed at 1 year were National Health Service hospital costs and quality of life. Prespecified secondary outcomes included clinical events. RESULTS: In the angiography+FFR arm, the median number of vessels examined was 4 (interquartile range, 3-5). The median hospital costs were similar: angiography, £4136 (interquartile range, £2613-£7015); and angiography+FFR, £4510 (£2721-£7415; P=0.137). There was no difference in median quality of life using the visual analog scale of the EuroQol EQ-5D-5L: angiography, 75 (interquartile range, 60-87); and angiography+FFR, 75 (interquartile range, 60-90; P=0.88). The number of clinical events was as follows: deaths, 5 versus 8; strokes, 3 versus 4; myocardial infarctions, 23 versus 22; and unplanned revascularizations, 26 versus 33, with a composite hierarchical event rate of 8.7% (48 of 552) for angiography versus 9.5% (52 of 548) for angiography+FFR (P=0.64). CONCLUSIONS: A strategy of systematic FFR assessment compared with angiography alone did not result in a significant reduction in cost or improvement in quality of life. REGISTRATION: URL: https://www. CLINICALTRIALS: gov; Unique identifier: NCT01070771."}