{"id":"0daa36edf57f","type":"article","url":"https://hartvaat.nl/2023/02/01/hypertensieve-zwangerschapscomplicaties-en-dementierisico-meta-analyse/","title":"Hypertensieve zwangerschapscomplicaties en dementierisico: meta-analyse","title_en":"Association Between Hypertensive Disorders of Pregnancy and Dementia: a Systematic Review and Meta-Analysis.","category":"hypertensie","category_label":"Hypertensie","professions":["cardioloog","huisarts"],"tags":["bloeddrukbehandeling","bradycardie","hypertrofische-cardiomyopathie","zwangerschap-hart"],"journal":"Hypertension (Dallas, Tex. : 1979)","doi":"10.1161/HYPERTENSIONAHA.122.19399","source_url":"https://doi.org/10.1161/HYPERTENSIONAHA.122.19399","authors":["Karen C Schliep","Hailey Mclean","Bin Yan","Fares Qeadan","Lauren H Theilen","Adam de Havenon","Jennifer J Majersik","Truls Østbye","Surendra Sharma","Michael W Varner"],"significance":6,"published":"2023-02-01","source_date":"2023-02-01","image":"","kennis":["https://hartvaat.nl/kennis/hypertensie/hypertensie-en-zwangerschap/","https://hartvaat.nl/kennis/hypertensie/eindorgaanschade-hypertensie/"],"congress":"","summary_en":"This meta-analysis showed that hypertensive disorders of pregnancy are associated with increased risk of later dementia, establishing gestational hypertension as a risk factor for long-term neurodegenerative disease.","created":"2026-07-03T10:30:12Z","updated":"2026-07-03T18:39:00Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Systematische review toonde dat hypertensieve zwangerschapsstoornissen geassocieerd zijn met een verhoogd risico op latere dementie. Dit versterkt het concept dat zwangerschap een cardiometabool 'stresstest' is met langetermijngevolgen voor hersenveroudering.","abstract_original":"BACKGROUND: Prior meta-analyses report a 2- to 4-fold increased risk of later cardiovascular disease among women with a history of hypertensive disorders of pregnancy (HDP). Given HDP's vascular underpinnings, it is hypothesized to also be a risk factor for later dementia. We aim to summarize the evidence for the impact of HDP on dementia and consider unique associations between HDP and dementia subtypes. METHODS: Observational studies on the relationship between HDP and dementia were identified from online electronic databases to July 1, 2021 (PROSPERO identifier: CRD42020185630). We included observational studies published in English. Exposure among women was any HDP and HDP subtypes: gestational hypertension, preeclampsia/eclampsia, or other/unspecified HDP. Outcome was any dementia and dementia subtypes: Alzheimer's disease, vascular dementia, or other/unspecified dementias. RESULTS: For our primary analyses, we included 5 cohort studies with a total of 183 874 women with and 2 309 705 women without HDP. Pooled analysis found a 38% higher risk of all-cause dementia among women with, versus without, any type of HDP (adjusted hazard ratio, 1.38 [95% CI, 1.18-1.61]; P<0.01). When examining association by HDP and dementia subtypes, we found that women with, versus without, any type of HDP had over a 3-fold higher risk of vascular dementia (adjusted hazard ratio, 3.14 [95% CI, 2.32-4.24]; P<0.01). CONCLUSIONS: Our findings indicate that maternal history of HDP is an important risk factor for later development of vascular and all-cause dementia. Further research among more racially/ethnically diverse populations quantifying HDP's effect on all-cause dementia, and specifically vascular dementia, is warranted."}