{"id":"4870b4335fed","type":"article","url":"https://hartvaat.nl/2023/03/01/diastolische-bloeddruk-en-cognitie-bij-intensieve-behandeling-sprint-mind/","title":"Diastolische bloeddruk en cognitie bij intensieve behandeling: SPRINT MIND","title_en":"Diastolic Blood Pressure and Intensive Blood Pressure Control on Cognitive Outcomes: Insights From the SPRINT MIND Trial.","category":"hypertensie","category_label":"Hypertensie","professions":["cardioloog","huisarts","internist"],"tags":[],"journal":"Hypertension (Dallas, Tex. : 1979)","doi":"10.1161/HYPERTENSIONAHA.122.20112","source_url":"https://doi.org/10.1161/HYPERTENSIONAHA.122.20112","authors":["Chao Jiang","Sitong Li","Yufeng Wang","Yiwei Lai","Yu Bai","Manlin Zhao","Liu He","Yu Kong","Xueyuan Guo","Songnan Li","Nian Liu","Chenxi Jiang","Ribo Tang","Caihua Sang","Deyong Long","Xin Du","Jianzeng Dong","Craig S Anderson","Changsheng Ma"],"significance":7,"published":"2023-03-01","source_date":"2023-03-01","image":"","kennis":["https://hartvaat.nl/kennis/hypertensie/behandeldoelen-bloeddruk/","https://hartvaat.nl/kennis/hypertensie/hypertensie-en-ckd/"],"congress":"","summary_en":"This SPRINT MIND analysis showed that the cognitive benefit of intensive systolic blood pressure control is maintained even in patients with low diastolic blood pressure, addressing the concern that aggressive systolic lowering might compromise cerebral perfusion.","created":"2026-07-03T10:30:16Z","updated":"2026-07-03T13:29:20Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"SPRINT MIND-analyse toonde dat intensieve systolische bloeddrukcontrole het cognitieve voordeel behoudt ook bij lage diastolische waarden. Lage diastolische druk bij intensieve therapie leidde niet tot slechtere cognitieve uitkomsten of cerebrale doorbloeding.","abstract_original":"BACKGROUND: The potential benefits or harms of intensive systolic blood pressure (BP) control on cognitive function and cerebral blood flow in individuals with low diastolic blood pressure (DBP) remain unclear. METHODS: We conducted a post hoc analysis of the SPRINT MIND (Systolic Blood Pressure Intervention Trial Memory and Cognition in Decreased Hypertension) that randomly assigned hypertensive participants to an intensive (<120 mm Hg; n=4278) or standard (<140 mm Hg; n=4385) systolic blood pressure target. We evaluated the effects of BP intervention on cognitive outcomes and cerebral blood flow across baseline DBP quartiles. RESULTS: Participants in the intensive group had a lower incidence rate of probable dementia or mild cognitive impairment than those in the standard group, regardless of DBP quartiles. The hazard ratio of intensive versus standard target for probable dementia or mild cognitive impairment was 0.91 (95% CI, 0.73-1.12) in the lowest DBP quartile and 0.70 (95% CI, 0.48-1.02) in the highest DBP quartile, respectively, with an interaction P value of 0.24. Similar results were found for probable dementia (interaction P=0.06) and mild cognitive impairment (interaction P=0.80). The effect of intensive treatment on cerebral blood flow was not modified by baseline DBP either (interaction P=0.25). Even among participants within the lowest DBP quartile, intensive versus standard BP treatment resulted in an increasing trend of annualized change in cerebral blood flow (+0.26 [95% CI, -0.72 to 1.24] mL/[100 g·min]). CONCLUSIONS: Intensive BP control did not appear to have a detrimental effect on cognitive outcomes and cerebral perfusion in patients with low baseline DBP. REGISTRATION: URL: https://www. CLINICALTRIALS: gov; Unique identifier: NCT01206062."}