# Cardiometabole gezondheid bij kinderen geboren na IVF

*geplaatst 2023-04-21 · Hypertensie · European heart journal · doi 10.1093/eurheartj/ehac726 · https://hartvaat.nl/2023/04/21/cardiometabole-gezondheid-bij-kinderen-geboren-na-ivf/*

Multi-cohort analyse toonde dat kinderen geboren na geassisteerde reproductietechnologie een iets ongunstiger cardiometabool profiel hebben dan natuurlijk verwekte kinderen. De verschillen zijn klein maar verdienen langetermijnmonitoring.

## English: Long-term cardiometabolic health in people born after assisted reproductive technology: a multi-cohort analysis.

This multi-cohort analysis showed that children born after assisted reproductive technology have a slightly less favorable cardiometabolic profile compared with naturally conceived children, warranting long-term cardiovascular follow-up.

## Abstract (original, from the publication)

AIMS: To examine associations of assisted reproductive technology (ART) conception (vs. natural conception: NC) with offspring cardiometabolic health outcomes and whether these differ with age. METHODS AND RESULTS: Differences in systolic (SBP) and diastolic blood pressure (DBP), heart rate (HR), lipids, and hyperglycaemic/insulin resistance markers were examined using multiple linear regression models in 14 population-based birth cohorts in Europe, Australia, and Singapore, and results were combined using meta-analysis. Change in cardiometabolic outcomes from 2 to 26 years was examined using trajectory modelling of four cohorts with repeated measures. 35 938 (654 ART) offspring were included in the meta-analysis. Mean age ranged from 13 months to 27.4 years but was <10 years in 11/14 cohorts. Meta-analysis found no statistical difference (ART minus NC) in SBP (-0.53 mmHg; 95% CI:-1.59 to 0.53), DBP (-0.24 mmHg; -0.83 to 0.35), or HR (0.02 beat/min; -0.91 to 0.94). Total cholesterol (2.59%; 0.10-5.07), HDL cholesterol (4.16%; 2.52-5.81), LDL cholesterol (4.95%; 0.47-9.43) were statistically significantly higher in ART-conceived vs. NC offspring. No statistical difference was seen for triglycerides (TG), glucose, insulin, and glycated haemoglobin. Long-term follow-up of 17 244 (244 ART) births identified statistically significant associations between ART and lower predicted SBP/DBP in childhood, and subtle trajectories to higher SBP and TG in young adulthood; however, most differences were not statistically significant. CONCLUSION: These findings of small and statistically non-significant differences in offspring cardiometabolic outcomes should reassure people receiving ART. Longer-term follow-up is warranted to investigate changes over adulthood in the risks of hypertension, dyslipidaemia, and preclinical and clinical cardiovascular disease.

Auteurs: Ahmed Elhakeem, Amy E Taylor, Hazel M Inskip, Jonathan Y Huang, Toby Mansell, Carina Rodrigues, Federica Asta, Sophia M Blaauwendraad, Siri E Håberg, Jane Halliday, Margreet W Harskamp-van Ginkel, Jian-Rong He, Vincent W V Jaddoe, Sharon Lewis, Gillian M Maher, Yannis Manios, Fergus P McCarthy, Irwin K M Reiss, Franca Rusconi, Theodosia Salika, Muriel Tafflet, Xiu Qiu, Bjørn O Åsvold, David Burgner, Jerry K Y Chan, Luigi Gagliardi, Romy Gaillard, Barbara Heude, Maria C Magnus, George Moschonis, Deirdre Murray, Scott M Nelson, Daniela Porta, Richard Saffery, Henrique Barros, Johan G Eriksson, Tanja G M Vrijkotte, Deborah A Lawlor

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Bron: European heart journal, https://doi.org/10.1093/eurheartj/ehac726. Bijgewerkt 2026-07-03T13:29:25Z. Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.