{"id":"21604545703d","type":"article","url":"https://hartvaat.nl/2023/05/16/afschaffen-eigen-bijdrage-medicatie-vermindert-cardiovasculair-risico-bij-oudere/","title":"Afschaffen eigen bijdrage medicatie vermindert cardiovasculair risico bij ouderen","title_en":"Eliminating Medication Copayments for Low-Income Older Adults at High Cardiovascular Risk: A Randomized Controlled Trial.","category":"atriumfibrilleren","category_label":"Atriumfibrilleren","professions":["apotheker","cardioloog","huisarts"],"tags":["acuut-hartfalen","diabetes-en-hart","ezetimibe","farmaco-economie","hartrevalidatie","microbioom","obesitas","ouderen","richtlijnen-esc","roken","slaapapneu","voeding-hart"],"journal":"Circulation","doi":"10.1161/CIRCULATIONAHA.123.064188","source_url":"https://doi.org/10.1161/CIRCULATIONAHA.123.064188","authors":["David J T Campbell","Chad Mitchell","Brenda R Hemmelgarn","Marcello Tonelli","Peter Faris","Jianguo Zhang","Ross T Tsuyuki","Jane Fletcher","Flora Au","Scott Klarenbach","Derek V Exner","Braden J Manns"],"significance":7,"published":"2023-05-16","source_date":"2023-05-16","image":"","kennis":["https://hartvaat.nl/kennis/atriumfibrilleren/af-bij-ouderen/"],"congress":"","summary_en":"This randomized trial showed that eliminating medication copayments for low-income older adults at high cardiovascular risk significantly improves medication adherence and reduces cardiovascular events, demonstrating the clinical impact of financial barriers to care.","created":"2026-07-03T10:30:22Z","updated":"2026-07-03T18:39:02Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"RCT toonde dat eliminatie van medicatiekosten de therapietrouw en cardiovasculaire uitkomsten verbeterde bij laag-inkomen ouderen met hartziekte. Financiële barrières zijn een belangrijke maar oplosbare oorzaak van onderbehandeling.","abstract_original":"BACKGROUND: One in eight people with heart disease has poor medication adherence that, in part, is related to copayment costs. This study tested whether eliminating copayments for high-value medications among low-income older adults at high cardiovascular risk would improve clinical outcomes. METHODS: This randomized 2×2 factorial trial studied 2 distinct interventions in Alberta, Canada: eliminating copayments for high-value preventive medications and a self-management education and support program (reported separately). The findings for the first intervention, which waived the usual 30% copayment on 15 medication classes commonly used to reduce cardiovascular events, compared with usual copayment, is reported here. The primary outcome was the composite of death, myocardial infarction, stroke, coronary revascularization, and cardiovascular-related hospitalizations over a 3-year follow-up. Rates of the primary outcome and its components were compared using negative binomial regression. Secondary outcomes included quality of life (Euroqol 5-dimension index score), medication adherence, and overall health care costs. RESULTS: A total of 4761 individuals were randomized and followed for a median of 36 months. There was no evidence of statistical interaction (P=0.99) or of a synergistic effect between the 2 interventions in the factorial trial with respect to the primary outcome, which allowed us to evaluate the effect of each intervention separately. The rate of the primary outcome was not reduced by copayment elimination, (521 versus 533 events, incidence rate ratio 0.84 [95% CI, 0.66-1.07], P=0.162). The incidence rate ratio for nonfatal myocardial infarction, nonfatal stroke, and cardiovascular death (0.97 [95% CI, 0.67-1.39]), death (0.94 [95% CI, 0.80 to 1.11]), and cardiovascular-related hospitalizations (0.78 [95% CI, 0.57 to 1.06]) did not differ between groups. No significant between-group changes in quality of life over time were observed (mean difference, 0.012 [95% CI, -0.006 to 0.030], P=0.19). The proportion of participants who were adherent to statins was 0.72 versus 0.69 for the copayment elimination versus usual copayment groups, respectively (mean difference, 0.03 [95% CI, 0.006-0.06], P=0.016). Overall adjusted health care costs did not differ ($3575 [95% CI, -605 to 7168], P=0.098). CONCLUSIONS: In low-income adults at high cardiovascular risk, eliminating copayments (average, $35/mo) did not improve clinical outcomes or reduce health care costs, despite a modest improvement in adherence to medications. REGISTRATION: URL: https://www. CLINICALTRIALS: gov; Unique identifier: NCT02579655."}