# HFA-PEFF score voor HFpEF-diagnose: validatie meta-analyse

*geplaatst 2023-08-01 · Hartfalen · ESC heart failure · doi 10.1002/ehf2.14421 · https://hartvaat.nl/2023/08/01/hfa-peff-score-voor-hfpef-diagnose-validatie-meta-analyse/*

Meta-analyse valideerde de HFA-PEFF score voor de diagnose van HFpEF. De score toonde goede diagnostische nauwkeurigheid en kan de complexe HFpEF-diagnose standaardiseren.

## English: Validation of heart failure algorithm for diagnosing heart failure with preserved ejection fraction: a meta-analysis.

This meta-analysis validated the HFA-PEFF diagnostic score for HFpEF, confirming good diagnostic accuracy and supporting its clinical utility for standardized evaluation of suspected heart failure with preserved ejection fraction.

## Abstract (original, from the publication)

The aim of the meta-analysis was to generate a more comprehensive understanding of the HFA-PEFF score in the diagnosis of heart failure with preserved ejection fraction (HFpEF) and to pose clues in the field of scientific and clinical practice. Electronic databases of PubMed, Web of Science, Cochrane Library, and Embase were systematically searched. Studies investigating the use of the HFA-PEFF score to diagnose HFpEF were included. Pooled sensitivity, specificity, positive likelihood ratio (PLR) and negative Likelihood Ratio (NLR), diagnostic odds ratio (DOR), area under the curve of summary receiver operating characteristic, and superiority index were calculated. Five studies with 1521 participants were included in this meta-analysis. In the pooled analysis of the 'Rule-out' approach, the pooled sensitivity, specificity, PLR, NLR, and DOR were 0.98 (0.94, 1.00), 0.33 (0.08, 0.73), 1.5 (0.8, 2.5), 0.05 (0.02, 0.17), and 28 (6, 127). In the pooled analysis of the 'Rule-in' approach, the pooled sensitivity and specificity, PLR, NLR, and DOR were 0.69 (0.62, 0.75), 0.87 (0.64, 0.96), 5.5 (1.8, 16.9), 0.35 (0.30, 0.41), and 16 (5, 50). This meta-analysis indicates that the HFA-PEFF algorithm showed acceptable specificity and sensitivity for the diagnosis and exclusion of HFpEF. More relevant studies on the diagnostic validity of the HFA-PEFF score are needed in the future.

Auteurs: Shu Li, Xiaomei Zhu, Yunlong Zhang, Fengjie Li, Shubin Guo

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Bron: ESC heart failure, https://doi.org/10.1002/ehf2.14421. Bijgewerkt 2026-07-03T13:29:34Z. Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.