# OCTIVUS: OCT-geleide versus IVUS-geleide PCI — non-inferioriteit bevestigd

*geplaatst 2023-10-17 · Algemeen · Circulation · doi 10.1161/CIRCULATIONAHA.123.066429 · https://hartvaat.nl/2023/10/17/octivus-oct-geleide-versus-ivus-geleide-pci-non-inferioriteit-bevestigd/*

De OCTIVUS-trial toonde dat OCT-geleide PCI non-inferieur was aan IVUS-geleide PCI. Beide intravasculaire beeldvormingstechnieken zijn gelijkwaardig, wat de keuze laat aan lokale expertise en beschikbaarheid.

## English: Optical Coherence Tomography-Guided or Intravascular Ultrasound-Guided Percutaneous Coronary Intervention: The OCTIVUS Randomized Clinical Trial.

The OCTIVUS trial demonstrated that OCT-guided PCI was noninferior to IVUS-guided PCI for clinical outcomes. The result established OCT and IVUS as interchangeable intravascular imaging modalities for guiding coronary intervention.

## Abstract (original, from the publication)

BACKGROUND: Intravascular imaging-guided percutaneous coronary intervention (PCI) with intravascular ultrasound (IVUS) or optical coherence tomography (OCT) showed superior clinical outcomes compared with angiography-guided PCI. However, the comparative effectiveness of OCT-guided and IVUS-guided PCI regarding clinical outcomes is unknown. METHODS: In this prospective, multicenter, open-label, pragmatic trial, we randomly assigned 2008 patients with significant coronary artery lesions undergoing PCI in a 1:1 ratio to undergo either an OCT-guided or IVUS-guided PCI. The primary end point was a composite of death from cardiac causes, target vessel-related myocardial infarction, or ischemia-driven target-vessel revascularization at 1 year, which was powered for noninferiority of the OCT group compared with the IVUS group. Safety outcomes were also assessed. RESULTS: At 1 year, primary end point events occurred in 25 of 1005 patients (Kaplan-Meier estimate, 2.5%) in the OCT group and in 31 of 1003 patients (Kaplan-Meier estimate, 3.1%) in the IVUS group (absolute difference, -0.6 percentage points; upper boundary of one-sided 97.5% CI, 0.97 percentage points; P<0.001 for noninferiority). The incidence of contrast-induced nephropathy was similar (14 patients [1.4%] in the OCT group versus 15 patients [1.5%] in the IVUS group; P=0.85). The incidence of major procedural complications was lower in the OCT group than in the IVUS group (22 [2.2%] versus 37 [3.7%]; P=0.047), although imaging procedure-related complications were not observed. CONCLUSIONS: In patients with significant coronary artery lesions, OCT-guided PCI was noninferior to IVUS-guided PCI with respect to the incidence of a composite of death from cardiac causes, target vessel-related myocardial infarction, or ischemia-driven target-vessel revascularization at 1 year. The selected study population and lower-than-expected event rates should be considered in interpreting the trial. REGISTRATION: URL: https://www. CLINICALTRIALS: gov; Unique number: NCT03394079.

Auteurs: Do-Yoon Kang, Jung-Min Ahn, Sung-Cheol Yun, Seung-Ho Hur, Yun-Kyeong Cho, Cheol Hyun Lee, Soon Jun Hong, Subin Lim, Sang-Wook Kim, Hoyoun Won, Jun-Hyok Oh, Jeong Cheon Choe, Young Joon Hong, Yong-Hoon Yoon, Hoyun Kim, Yeonwoo Choi, Jinho Lee, Young Won Yoon, Soo-Joong Kim, Jang-Ho Bae, Duk-Woo Park, Seung-Jung Park

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Bron: Circulation, https://doi.org/10.1161/CIRCULATIONAHA.123.066429. Bijgewerkt 2026-07-03T13:29:41Z. Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.