{"id":"eecc79aded63","type":"article","url":"https://hartvaat.nl/2024/04/01/cardiorace-aeroob-krachttraining-of-gecombineerd-en-cardiovasculair-risicoprofie/","title":"CardioRACE: aeroob, krachttraining of gecombineerd en cardiovasculair risicoprofiel","title_en":"Aerobic, resistance, or combined exercise training and cardiovascular risk profile in overweight or obese adults: the CardioRACE trial.","category":"cholesterol","category_label":"Cholesterol","professions":["cardioloog","huisarts"],"tags":["hartrevalidatie","slaapapneu"],"journal":"European heart journal","doi":"10.1093/eurheartj/ehad827","source_url":"https://doi.org/10.1093/eurheartj/ehad827","authors":["Duck-Chul Lee","Angelique G Brellenthin","Lorraine M Lanningham-Foster","Marian L Kohut","Yehua Li"],"significance":7,"published":"2024-04-01","source_date":"2024-04-01","image":"","kennis":["https://hartvaat.nl/kennis/preventie/preventie-bij-diabetes/","https://hartvaat.nl/kennis/lipiden/lipidenmedicatie-bij-ckd/"],"congress":"","summary_en":"The CardioRACE trial compared aerobic, resistance, and combined exercise training on cardiovascular risk profile in overweight adults, finding that combined training provides the most comprehensive cardiovascular risk factor improvement.","created":"2026-07-03T10:30:51Z","updated":"2026-07-03T13:29:53Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"De CardioRACE-trial vergeleek aerobe, kracht- en gecombineerde training op het CV-risicoprofiel bij overgewichtige volwassenen. Gecombineerde training gaf de beste resultaten, wat geïntegreerde trainingsprogramma's in de CV-preventie ondersteunt.","abstract_original":"BACKGROUND AND AIMS: To determine the comparative efficacy of resistance, aerobic, and combined resistance plus aerobic exercise on cardiovascular disease (CVD) risk profile. METHODS: This randomized controlled trial enrolled 406 adults aged 35-70 years with overweight or obesity and elevated blood pressure. Participants were randomly assigned to resistance (n = 102), aerobic (n = 101), combined resistance plus aerobic exercise (n = 101), or no-exercise control (n = 102). All exercise participants were prescribed 1 h of time-matched supervised exercise (the combination group with 30 min of each resistance and aerobic exercise) three times per week for 1 year. The primary outcome was the change from baseline to 1 year in the standardized composite Z-score of four well-established CVD risk factors: systolic blood pressure, low-density lipoprotein (LDL) cholesterol, fasting glucose, and per cent body fat. RESULTS: Among 406 participants (53% women), 381 (94%) completed 1-year follow-up. Compared with the control group, the composite Z-score decreased at 1 year, which indicates improved CVD risk profile, in the aerobic {mean difference, -0.15 [95% confidence interval (CI): -0.27 to -0.04]; P = .01} and combination [mean difference, -0.16 (95% CI: -0.27 to -0.04); P = .009] groups, but not in the resistance [mean difference, -0.02 (95% CI: -0.14 to 0.09); P = .69] group. Both aerobic and combination groups had greater reductions in the composite Z-score compared with the resistance group (both P = .03), and there was no difference between the aerobic and combination groups (P = .96). Regarding the four individual CVD risk factors, only per cent body fat decreased in all three exercise groups at 1 year, but systolic blood pressure, LDL cholesterol, and fasting glucose did not decrease in any exercise groups, compared with the control group. CONCLUSIONS: In adults with overweight or obesity, aerobic exercise alone or combined resistance plus aerobic exercise, but not resistance exercise alone, improved composite CVD risk profile compared with the control."}