# Triglyceride-glucose-index en CV-uitkomsten na PCI: Chinese meta-analyse

*geplaatst 2024-06-01 · Cholesterol · ESC heart failure · doi 10.1002/ehf2.14679 · https://hartvaat.nl/2024/06/01/triglyceride-glucose-index-en-cv-uitkomsten-na-pci-chinese-meta-analyse/*

Meta-analyse toonde dat de triglyceride-glucose (TyG)-index cardiovasculaire uitkomsten na PCI voorspelt. Deze eenvoudige insulineresistentiemarker kan de risicostratificatie na PCI verbeteren.

## English: Triglyceride-glucose index's link to cardiovascular outcomes post-percutaneous coronary intervention in China: a meta-analysis.

A meta-analysis of Chinese studies demonstrated that the triglyceride-glucose index, a simple surrogate marker of insulin resistance, predicts major adverse cardiovascular events after percutaneous coronary intervention. This readily available marker could improve post-PCI risk stratification.

## Abstract (original, from the publication)

Percutaneous coronary intervention (PCI) addresses myocardial ischaemia, but a significant subset of patients encounter major adverse cardiovascular events (MACE) post-treatment. This meta-analysis investigated the relationship between the post-PCI triglyceride-glucose (TyG) index and MACE. Comprehensive searches of the Embase, PubMed, Cochrane Library, and Web of Science databases were conducted up to 3 March 2023, using relevant keywords. The effect size was determined based on I2 statistic using random-effects models. Cluster-robust standard errors crafted the dose-response curve, and the GRADE Evaluation Scale was employed to rate the quality of evidence. The group with the highest TyG index had significantly higher post-PCI MACE rates than the lowest index group, with hazard ratios (HRs) of 2.04 (95% CI 1.65-2.52; I2 = 77%). Each unit increase in TyG index corresponded to HRs of 1.82 for MACE (95% CI 1.34-2.46; I2 = 92%), 2.57 for non-fatal MI (95% CI 1.49-4.41; I2 = 63%), and 2.06 for revascularization (95% CI 1.23-3.50; I2 = 90%). A linear relationship between TyG index and MACE risk was established (R2 = 0.6114). For all-cause mortality, the HR was 1.93 (95% CI 1.35-2.75; I2 = 50%), indicating a higher mortality risk with elevated TyG index. The GRADE assessment yielded high certainty for non-fatal MI but low certainty for all-cause mortality, revascularization, and MACE. The TyG index may predict risks of post-PCI MACE, all-cause mortality, non-fatal MI, and revascularization, with varied levels of certainty. A potential linear association between the TyG index and MACE post-PCI was identified. Future research should validate these findings.

Auteurs: ChangXin Sun, LanQing Hu, XiaoYa Li, XiaoNan Zhang, JiYe Chen, DeXiu Li, JingYi Zhang, LongTao Liu, Min Wu

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Bron: ESC heart failure, https://doi.org/10.1002/ehf2.14679. Bijgewerkt 2026-07-03T13:29:59Z. Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.