{"id":"b1fe86433eca","type":"article","url":"https://hartvaat.nl/2025/07/01/ventriculaire-aritmieen-na-lvad-implantatie-meta-analyse/","title":"Ventriculaire aritmieën na LVAD-implantatie: meta-analyse","title_en":"Ventricular arrhythmias following left ventricular assist device implantation: a systematic review and meta-analysis of incidence and clinical impact.","category":"hartfalen","category_label":"Hartfalen","professions":["cardioloog"],"tags":["ventrikelfibrilleren"],"journal":"Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology","doi":"10.1093/europace/euaf129","source_url":"https://doi.org/10.1093/europace/euaf129","authors":["Miloud Cherbi","Paul Gautier","Frederic Sacher","Raphael Martins","Sebastien Knecht","Philippe Maury","Clément Delmas"],"significance":5,"published":"2025-07-01","source_date":"2025-07-01","image":"","kennis":[],"congress":"","summary_en":"A meta-analysis documented the incidence and clinical impact of ventricular arrhythmias following left ventricular assist device implantation. Arrhythmias were frequent and associated with worse outcomes, supporting proactive monitoring and consideration of prophylactic strategies.","created":"2026-07-03T10:31:42Z","updated":"2026-07-03T13:30:43Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Meta-analyse documenteerde de incidentie en risicofactoren van ventriculaire aritmieën na LVAD. Aritmieën zijn frequent en geassocieerd met slechtere uitkomsten, wat proactieve monitoring en profylaxe vereist.","abstract_original":"AIMS: Ventricular arrhythmias (VAs) occur frequently following left ventricular assist device (LVAD) implantation. However, current evidence regarding their true incidence and impact remains limited. METHODS AND RESULTS: We performed a systematic review and meta-analysis to assess the incidence and impact of post-LVAD VAs. PubMed/Embase/Cochrane databases were searched from inception to 1 April 2025, for studies reporting the occurrence of VAs following LVAD implantation. The primary outcome was the overall incidence of VAs. Secondary outcomes included the incidence of early (≤30 days) and late (>30 days) VAs, as well as electrical storm (ES) and their impact on all-cause mortality, assessed using incidence rate ratios (IRRs). Forty studies including 22 181 patients were analysed. The overall incidence of post-LVAD VAs was 2.43 (1.70-3.48) events per 100 person-months. Ventricular arrhythmia occurrence was significantly associated with increased all-cause mortality [IRR 1.32 (1.11-1.57)). The incidence of early VAs was 0.65 (0.48-0.88) events per 100 person-days (19.5 events per 100 patients over 30 days), and early VAs were associated with a higher risk of mortality [IRR 1.40 (1.18-1.67)]. Conversely, the incidence of late VAs was 2.05 (1.43-2.93) events per 100 person-months and was not significantly associated with mortality [IRR 0.85 (0.66-1.10)]. Electrical storm incidence was 0.44 (0.07-2.71) events per 100 person-months, significantly increasing all-cause mortality [IRR 1.34 (1.01-1.79)]. CONCLUSION: Ventricular arrhythmias are frequent following LVAD implantation and are associated with a significant impact on all-cause mortality-particularly when occurring early after implantation. Further studies are needed to optimize VA management and implantable cardioverter-defibrillator use."}