{"id":"8a400cef86e7","type":"article","url":"https://hartvaat.nl/2025/08/01/inspanningsmodaliteiten-en-fysieke-functie-bij-hfpef-meta-analyse/","title":"Inspanningsmodaliteiten en fysieke functie bij HFpEF: meta-analyse","title_en":"Effects of exercise modalities on physical function and quality of life in patients with heart failure: A systematic review and network meta-analysis.","category":"hartfalen","category_label":"Hartfalen","professions":["cardioloog","huisarts"],"tags":[],"journal":"ESC heart failure","doi":"10.1002/ehf2.15256","source_url":"https://doi.org/10.1002/ehf2.15256","authors":["Jiang-Ying Li","Lu Chen","Qiu-Chen Wang","Jian Zhu","Zhen-Qing Ren","Li-Chun Wang"],"significance":5,"published":"2025-08-01","source_date":"2025-08-01","image":"","kennis":["https://hartvaat.nl/kennis/hartfalen/palliatief-hartfalen/"],"congress":"","summary_en":"A network meta-analysis compared exercise modalities for physical function and quality of life in heart failure. Combined aerobic and resistance training provided the greatest benefits, while yoga showed particular promise for left ventricular function improvement.","created":"2026-07-03T10:31:45Z","updated":"2026-07-03T13:30:45Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Meta-analyse vergeleek inspanningsmodaliteiten op fysieke functie en kwaliteit van leven bij HFpEF. Gecombineerde aerobe en krachttraining gaf de grootste voordelen.","abstract_original":"AIMS: This study aimed to evaluate the effects of various exercise modalities on physical function and quality of life in individuals with heart failure and to identify the most effective approaches. METHODS AND RESULTS: A network meta-analysis was conducted by searching PubMed, Embase and the Cochrane Library databases. Random-effects meta-analyses were performed to estimate mean differences (MD) and 95% confidence intervals (CI). A total of 60 randomized controlled trials, comprising 3261 participants, were included in the analysis. Yoga was associated with the greatest improvement in left ventricular ejection fraction (P-score = 0.91, MD: 0.90; 95% CI: 0.42 to 1.38) and the most significant reduction in serum natriuretic peptide levels (P-score = 0.965, MD: -1.46; 95% CI: -1.88 to -1.04). Interval training demonstrated superior effectiveness in increasing the 6-min walk distance (6MWD) (P-score = 0.873, MD: 113.01; 95% CI: 28.55 to 197.47). Combined aerobic and resistance training (AT + RT) showed the greatest benefits in enhancing peak oxygen uptake (VO2peak) (P-score = 0.829, MD: 3.68; 95% CI: 2.23 to 5.13). High-intensity interval training combined with inspiratory muscle training (HIIT + IMT) yielded the most significant improvements in quality of life (P-score = 0.871, MD: -19.28; 95% CI: -26.42 to -12.14) and the greatest reduction in dyspnea (P-score = 0.804, MD: -1.58; 95% CI: -2.64 to -0.52). CONCLUSIONS: Current evidence suggests that yoga, interval training, AT + RT, and HIIT + IMT significantly enhance physical function and quality of life in individuals with heart failure, with each modality exhibiting distinct advantages. Further high-quality studies are warranted to confirm these findings and refine exercise prescriptions for this population."}