{"id":"baaf4f20f1db","type":"article","url":"https://hartvaat.nl/2025/08/26/hepa-luchtzuivering-en-bloeddruk-pragmatische-cross-over-trial/","title":"HEPA-luchtzuivering en bloeddruk: pragmatische cross-over trial","title_en":"Effect of HEPA Filtration Air Purifiers on Blood Pressure: A Pragmatic Randomized Crossover Trial.","category":"hypertensie","category_label":"Hypertensie","professions":["cardioloog","huisarts"],"tags":[],"journal":"Journal of the American College of Cardiology","doi":"10.1016/j.jacc.2025.06.037","source_url":"https://doi.org/10.1016/j.jacc.2025.06.037","authors":["Doug Brugge","Misha Eliasziw","Mohan Thanikachalam","Vedaant Kuchhal","Chermaine Morson","Teresa Vazquez-Dodero","Amy Mertl","Pratham Tallam","Sangita Kunwar","Linda Sprague Martinez","Humza Shamoon Rashid","Kiran Singh-Smith","Hunter Gates","Sharly Palma","Warren Goldstein-Gelb","Shir Lerman Ginzburg","Scott Oakley Hersey","Francesca Majluf","Wig Zamore"],"significance":5,"published":"2025-08-26","source_date":"2025-08-26","image":"","kennis":[],"congress":"","summary_en":"A pragmatic crossover trial tested whether HEPA air purifiers reduce blood pressure in adults living near highways. The blood pressure-lowering effect was limited, tempering expectations for air quality interventions as a hypertension management strategy.","created":"2026-07-03T10:31:49Z","updated":"2026-07-03T13:30:48Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Pragmatische trial onderzocht of HEPA-luchtzuivering de bloeddruk verlaagt. Het effect was beperkt, wat luchtkwaliteitsinterventies als bloeddrukstrategie nuanceert.","abstract_original":"BACKGROUND: Particulate matter (PM) pollution is a leading cause of cardiovascular risk and illness, including elevated blood pressure (BP). OBJECTIVES: The purpose of this study was to test the efficacy of in-home air purifiers to reduce BP for adults living adjacent to highways. METHODS: We conducted a pragmatic randomized crossover trial of the effect of high-efficiency particulate arrestance (HEPA) vs sham filtration on BP. Residences were randomized to start with 1 month of HEPA filtration or 1 month of sham filtration. A 1-month wash out period with no filtration was followed by 1 month of the alternate filtration. Participant questionnaire data and BP were collected 4 times, at the start and end of each filtration period. PM concentrations were measured in a subset of residences. Linear mixed models were used to compare the mean change in BP between the HEPA and sham filtration periods. Models were adjusted for time invariant and time-varying covariates. RESULTS: A total of 154 participants were analyzed. The mean age was 41.1 years, 59.7% were women, 68.2% were non-Hispanic White, and a majority were of higher socioeconomic status. The mean baseline brachial systolic blood pressure (SBP)/diastolic BP was 118.8/76.5 mm Hg. HEPA filtration significantly reduced PM in comparison to both indoor sham and outdoor levels. Participants' SBP at the start of the intervention period moderated the efficacy of the intervention (P = 0.03). Participants who had elevated brachial SBP (≥120 mm Hg) had a significant 2.8-mm Hg mean reduction in SBP after HEPA filtration (P = 0.03) and a 0.2-mm Hg mean increase in SBP after sham filtration (P = 0.85). The net result was a significant 3.0-mm Hg mean difference in favor of HEPA filtration (P = 0.04). There was no significant benefit on diastolic BP or for participants with normal SBP (<120 mm Hg). CONCLUSIONS: The use of in-home HEPA air purifiers resulted in clinically important reductions in SBP for people with elevated SBP in environments with relatively low PM2.5 concentrations."}