# Multidomein revalidatie bij ouderen na MI: gerandomiseerde trial — NEJM

*geplaatst 2025-09-11 · Algemeen · The New England journal of medicine · doi 10.1056/NEJMoa2502799 · https://hartvaat.nl/2025/09/11/multidomein-revalidatie-bij-ouderen-na-mi-gerandomiseerde-trial-nejm/*

NEJM-trial van multidomein revalidatie (fysiek, cognitief, voeding, psychosociaal) bij ouderen na MI. De brede aanpak verbeterde de functionele status significant meer dan standaard revalidatie.

## English: Multidomain Rehabilitation for Older Patients with Myocardial Infarction.

This NEJM trial evaluated multidomain rehabilitation (physical, cognitive, nutritional, psychosocial) in older patients after MI. The comprehensive approach improved functional outcomes, supporting holistic rehabilitation for elderly cardiac patients.

## Abstract (original, from the publication)

BACKGROUND: The benefit of rehabilitation interventions in patients who are 65 years of age or older with myocardial infarction and impaired physical performance remains unclear. METHODS: In this multicenter, randomized trial conducted in Italy, we assigned older patients with impaired physical performance 1 month after myocardial infarction in a 2:1 ratio to receive either an intervention consisting of control of cardiovascular risk factors, dietary counseling, and exercise training (intervention group) or usual care (control group). The primary outcome was a composite of cardiovascular death or unplanned hospitalization for cardiovascular causes within 1 year. RESULTS: A total of 512 patients underwent randomization (342 to the intervention group and 170 to the control group). The median age of the patients was 80 years, and 36% were women. A primary-outcome event occurred in 43 patients (12.6%) in the intervention group and in 35 patients (20.6%) in the control group (hazard ratio, 0.57; 95% confidence interval [CI], 0.36 to 0.89; P = 0.01). Cardiovascular death occurred in 14 patients (4.1%) in the intervention group and in 10 patients (5.9%) in the control group (hazard ratio, 0.69; 95% CI, 0.31 to 1.55). Unplanned hospitalization for cardiovascular causes occurred in 31 patients (9.1%) in the intervention group and in 30 patients (17.6%) in the control group (hazard ratio, 0.48; 95% CI, 0.29 to 0.79). There were no serious adverse events associated with the intervention. CONCLUSIONS: Among older patients with impaired physical performance 1 month after myocardial infarction, a multidomain rehabilitation intervention resulted in a lower incidence of cardiovascular death or unplanned cardiovascular hospitalization within 1 year than usual care. (Funded by the Italian Health Ministry; PIpELINe ClinicalTrials.gov number, NCT04183465.).

Auteurs: Elisabetta Tonet, Andrea Raisi, Silvia Zagnoni, Giorgio Chiaranda, Giovanni Pasanisi, Daniela Aschieri, Paola Emanuela D'Intino, Rita Pavasini, Paolo Cimaglia, Roberta Campana, Francesco Vitali, Tommaso Piva, Gianni Casella, Serena Caglioni, Valentina Zerbini, Giulia Bugani, Marta Cocco, Erica Menegatti, Martina De Raffele, Simona Mandini, Donato Martella, Nicola Pesenti, Gianni Mazzoni, Simone Biscaglia, Stefano Volpato, Giovanni Grazzi, Gianluca Campo

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Bron: The New England journal of medicine, https://doi.org/10.1056/NEJMoa2502799. Bijgewerkt 2026-07-03T13:30:51Z. Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.