# Granzyme K zet het complementsysteem in beweging

*geplaatst 2025-09-30 · Nierziekte · Kidney International · doi https://www.kidney-international.org/article/S0085-2538(25)00752-5/fulltext · https://hartvaat.nl/2025/09/30/granzyme-k-zet-het-complementsysteem-in-beweging/*

Het complementsysteem bewaakt circulatie en weefsels zoals de nier. Naast gastheerdefensie drijft het ook inflammatie. Dit commentaar bespreekt hoe granzyme K complementactivatie initieert bij nierziekte.

## English: Granzyme K sets complement in motion

This commentary discusses how granzyme K initiates complement activation in kidney disease. The complement system, comprising nearly 50 proteins, functions as a surveillance mechanism in circulation and tissues, with emerging therapeutic implications for nephrology.

## Abstract (original, from the publication)

The complement system, comprising nearly 50 proteins, functions as a surveillance system in circulation and tissues such as the kidney. While critical for host defense against pathogens, it also drives inflammation in various diseases. Recently, the clinical use of complement inhibitors has surged,1 with the latest Food and Drug Administration approvals in IgA nephropathy and C3 glomerulopathy. Still, the complement system is frequently oversimplified as "merely" a downstream mediator of antibodies, which represents only one aspect of its multifaceted role.

Auteurs: Felix Poppelaars, Mohamed R. Daha

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Bron: Kidney International, https://doi.org/https://www.kidney-international.org/article/S0085-2538(25)00752-5/fulltext. Bijgewerkt 2026-07-03T13:25:06Z. Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.