# Peptidedeformylase reguleert aldosteronproductie via calbindine 1

*geplaatst 2025-10-17 · Hypertensie · Hypertension · doi https://www.ahajournals.org/doi/abs/10.1161/HYPERTENSIONAHA.124.24395 · https://hartvaat.nl/2025/10/17/peptidedeformylase-reguleert-aldosteronproductie-via-calbindine-1/*

Aldosteron-producerende adenomen zijn een belangrijke oorzaak van primair aldosteronisme. De moleculaire mechanismen zijn onvolledig begrepen. Dit onderzoek toont dat peptidedeformylase de aldosteronproductie reguleert via calbindine 1.

## English: Peptide Deformylase Regulates Aldosterone Production Through Calbindin 1

This study demonstrates that peptide deformylase, essential for maturation of mitochondrially encoded proteins, regulates aldosterone production through calbindin 1 in aldosterone-producing adenomas, advancing understanding of primary aldosteronism pathogenesis.

## Abstract (original, from the publication)

Hypertension, Volume 83, Issue 5, Page e24395, May 1, 2026. BACKGROUND:Aldosterone-producing adenoma is a major cause of primary aldosteronism. However, the molecular mechanisms underlying aldosterone overproduction remain incompletely understood. The expression of peptide deformylase, which is essential for the maturation of mitochondrially encoded proteins, was significantly upregulated in our previous proteomic analysis. We aimed to elucidate the role of peptide deformylase in aldosterone overproduction.METHODS:Peptide deformylase expression was validated in enlarged aldosterone-producing adenoma samples harboring different mutations and in adrenocortical cell lines. A key protein exhibiting the most significant change was identified through proteomic analysis of peptide deformylase-knockdown cells and validated in vitro.RESULTS:Both peptide deformylase expression and aldosterone synthase (CYP11B2 [cytochrome P450 family 11 subfamily B member 2]) colocalization were significantly en

Auteurs: Mansi Luo

---
Bron: Hypertension, https://doi.org/https://www.ahajournals.org/doi/abs/10.1161/HYPERTENSIONAHA.124.24395. Bijgewerkt 2026-07-03T13:25:06Z. Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.