# Dynamische controle van Na-Cl-cotransporter door WNK1-kinase: bifasische respons op kalium

*geplaatst 2025-10-20 · Nierziekte · Kidney International · doi https://www.kidney-international.org/article/S0085-2538(25)00826-9/fulltext · https://hartvaat.nl/2025/10/20/dynamische-controle-van-na-cl-cotransporter-door-wnk1-kinase-bifasische-respons-/*

Bloeddruk wordt beïnvloed door zout- én kaliumconsumptie. Laag kalium is geassocieerd met hogere bloeddruk. Dit onderzoek beschrijft de dynamische controle van de Na-Cl-cotransporter door nierspecifiek WNK1-kinase via bifasische kaliumsignalering.

## English: Dynamic control of Na-Cl cotransporter by kidney-specific with-no-lysine 1 kinase: a biphasic response to K+ via condensate signaling

This research describes the dynamic control of the Na-Cl cotransporter by kidney-specific WNK1 kinase through a biphasic potassium signalling mechanism involving condensate formation. The findings explain how dietary potassium influences blood pressure via renal sodium handling.

## Abstract (original, from the publication)

Arterial blood pressure is influenced not only by salt intake but also by potassium (K+) consumption. Low dietary K+ is associated with higher blood pressure, whereas high K+ intake has a blood pressure–lowering effect. This is partly explained by the role of the Na-Cl cotransporter (NCC) in the distal convoluted tubule, which modulates K+ excretion. In the collecting duct, K+ excretion depends on the luminal negative voltage generated by the sodium reabsorption through the epithelial sodium channel ENaC, which, in turn, depends on the amount of sodium delivery due to the upstream activity of NCC.

Auteurs: Maria Chavez-Canales, Gerardo Gamba

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Bron: Kidney International, https://doi.org/https://www.kidney-international.org/article/S0085-2538(25)00826-9/fulltext. Bijgewerkt 2026-07-03T13:25:06Z. Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.