{"id":"9cae50e71348","type":"article","url":"https://hartvaat.nl/2025/10/22/lagere-cardiorespiratoire-fitheid-en-atherosclerose-ondanks-cac-score-nul-scapis/","title":"Lagere cardiorespiratoire fitheid en atherosclerose ondanks CAC-score nul (SCAPIS)","title_en":"Lower cardiorespiratory fitness is associated with coronary artery atherosclerosis in individuals with a zero CAC score – cross-sectional results from SCAPIS","category":"cholesterol","category_label":"Cholesterol","professions":["cardioloog","huisarts"],"tags":["calciumscore"],"journal":"Atherosclerosis","doi":"https://www.atherosclerosis-journal.com/article/S0021-9150(25)01448-0/fulltext","source_url":"https://doi.org/https://www.atherosclerosis-journal.com/article/S0021-9150(25)01448-0/fulltext","authors":["Frida Griffin","Jonatan Fridolfsson","Daniel Arvidsson","Elin Ekblom-Bak","Örjan Ekblom","Göran Bergström","Mats Börjesson"],"significance":5,"published":"2025-10-22","source_date":"2025-10-22","image":"","kennis":[],"congress":"","summary_en":"This SCAPIS cross-sectional study found that lower estimated cardiorespiratory fitness is associated with coronary atherosclerosis even in individuals with a zero coronary artery calcium score. Adding fitness to conventional risk models improved atherosclerosis risk prediction.","created":"2026-07-03T10:25:43Z","updated":"2026-07-03T13:25:06Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Ondanks een CAC-score van nul toont 5-6% van de middelbare volwassenen atherosclerose. Deze SCAPIS cross-sectionele studie onderzocht het verband tussen geschatte cardiorespiratoire fitheid en coronaire atherosclerose bij een CAC van nul.","abstract_original":"Despite a coronary artery calcification (CAC) score of zero, 5–6 % of middle-aged individuals still exhibit underlying atherosclerosis. This cross-sectional study aimed first to investigate the association between estimated cardiorespiratory fitness (CRF) and atherosclerosis in individuals with zero CAC, second to assess whether adding CRF to the Systematic Coronary Risk Evaluation (SCORE) model improves the explained variance in atherosclerosis, and third to characterise the association across CRF levels."}