# Rol van stressresponsief NR4A2 bij aldosteron-producerende celclustervorming

*geplaatst 2025-10-27 · Hypertensie · Hypertension · doi https://www.ahajournals.org/doi/abs/10.1161/HYPERTENSIONAHA.125.24825 · https://hartvaat.nl/2025/10/27/rol-van-stressresponsief-nr4a2-bij-aldosteron-producerende-celclustervorming/*

Aldosteron-producerende celclusters (APCC's) delen transcriptomische kenmerken met aldosteron-producerende adenomen en worden vaak gezien bij ouderen en primair aldosteronisme. Dit onderzoek onderzocht de rol van het stressresponsieve NR4A2 bij APCC-vorming.

## English: Role of Stress-Responsive NR4A2 in Aldosterone-Producing Cell Cluster Formation

This study identified the stress-responsive transcription factor NR4A2 as a key driver of aldosterone-producing cell cluster formation in the adrenal cortex. The findings advance understanding of primary aldosteronism pathogenesis and age-related aldosterone dysregulation.

## Abstract (original, from the publication)

Hypertension, Volume 83, Issue 5, Page e24825, May 1, 2026. BACKGROUND:Aldosterone-producing cell clusters (APCCs), which share some transcriptomic features with aldosterone-producing adenomas, are frequently observed in the adrenal cortex of aged individuals and those with primary aldosteronism. However, the mechanisms driving APCC formation remain poorly understood.METHODS:We performed an integrated analysis using spatial transcriptomics and single-cell RNA sequencing of APCC cells, aldosterone-producing adenoma cells, and zona glomerulosa (ZG) cells present in the same adrenal gland of a patient with unilateral primary aldosteronism, with validation analyses conducted on tissue samples from 2 additional patients.RESULTS:APCC cells exhibited a distinct cellular population with a gene expression profile more similar to that of the ZG cells than that of aldosterone-producing adenoma cells. In silico perturbation and in vitro studies suggest that the stress-responsive transcription fact

Auteurs: Norifusa Iwahashi

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Bron: Hypertension, https://doi.org/https://www.ahajournals.org/doi/abs/10.1161/HYPERTENSIONAHA.125.24825. Bijgewerkt 2026-07-03T13:25:06Z. Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.