{"id":"3c6e842fb2ec","type":"article","url":"https://hartvaat.nl/2025/10/28/esprit-bescheiden-effecten-van-intensieve-bloeddrukverlaging-op-kwaliteit-van-le/","title":"ESPRIT: bescheiden effecten van intensieve bloeddrukverlaging op kwaliteit van leven","title_en":"Modest Effects of Intensive Blood Pressure-Lowering on Quality of Life in Patients at High Cardiovascular Risk: The ESPRIT Trial.","category":"hypertensie","category_label":"Hypertensie","professions":["cardioloog","huisarts"],"tags":[],"journal":"Journal of the American College of Cardiology","doi":"10.1016/j.jacc.2025.06.010","source_url":"https://doi.org/10.1016/j.jacc.2025.06.010","authors":["Xinghe Huang","Haibo Zhang","Yan Li","Jinzhuo Ge","Ying Sun","Liping Zhang","Lingshan Zhao","Jiangling Liu","Chengbo Zhang","Jie Du","Yanfang Li","Hailin Zhang","Feng Hao","Qiuli Wang","Wei Xu","Jiamin Liu","Jing Li"],"significance":6,"published":"2025-10-28","source_date":"2025-10-28","image":"","kennis":["https://hartvaat.nl/kennis/hypertensie/behandeldoelen-bloeddruk/","https://hartvaat.nl/kennis/hypertensie/hypertensie-en-diabetes/"],"congress":"","summary_en":"This ESPRIT analysis confirmed that intensive blood pressure lowering does not significantly impair quality of life compared with standard treatment, addressing concerns that aggressive targets may reduce patient well-being.","created":"2026-07-03T10:31:56Z","updated":"2026-07-03T13:30:55Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"ESPRIT analyse toonde dat intensieve bloeddrukbehandeling de kwaliteit van leven niet significant beïnvloedt. De angst voor bijwerkingen bij intensieve therapie wordt niet bevestigd.","abstract_original":"BACKGROUND: Cumulative evidence supports the beneficial effects of intensive blood pressure (BP)-lowering treatment to prevent cardiovascular events and death; however, the effects of a more aggressive BP target on health-related quality of life (HRQoL) remain unclear. OBJECTIVES: This study aimed to compare the effects of intensive vs standard BP-lowering treatment strategies on long-term change in HRQoL among hypertensive patients with high cardiovascular risk. METHODS: The ESPRIT (Effects of Intensive Systolic Blood Pressure Lowering Treatment in Reducing Risk of Vascular Events) trial was an open-label, blinded-outcome, randomized controlled trial. Participants were randomly assigned to receive either intensive BP-lowering treatment (targeting standard office systolic blood pressure [SBP] to <120 mm Hg) or standard BP-lowering treatment (targeting office SBP to <140 mm Hg). HRQoL was assessed by using the 5-level EuroQol Five Dimensions Questionnaire (EQ-5D-5L) at baseline and the final follow-up visit. Covariance analyses were applied to evaluate the effect of treatment assignment on changes in HRQoL. RESULTS: The current study included 5,398 participants in the intensive treatment group and 5,406 participants in the standard treatment group. Over 3.4 years of follow-up, the EQ-5D visual analog scale scores increased by 0.56 point in the intensive treatment group and decreased by 0.50 point in the standard treatment group, resulting in a mean difference of 1.26 (95% CI: 0.55 to 1.98; P < 0.001). Compared with the standard treatment, the intensive treatment was associated with a 16% higher likelihood of meaningful improvement than worsening in EQ-5D visual analog scale (relative risk: 1.16; 95% CI: 1.04-1.30; P = 0.007). Categorical changes from baseline to the final follow-up visit in 5 domains between the 2 groups showed no statistical differences. CONCLUSIONS: Intensive BP treatment, targeting office SBP to <120 mm Hg, produced modest benefits to HRQoL among hypertensive patients with high cardiovascular risk. (Effects of Intensive Systolic Blood Pressure Lowering Treatment in Reducing Risk of Vascular Events [ESPRIT]; NCT04030234)."}