# Monocyten hun verdiende erkenning geven: CD47-SIRPα herkadert allograaftstoting

*geplaatst 2025-11-18 · Nierziekte · Kidney International · doi https://www.kidney-international.org/article/S0085-2538(25)00877-4/fulltext · https://hartvaat.nl/2025/11/18/monocyten-hun-verdiende-erkenning-geven-cd47-sirp-herkadert-allograaftstoting/*

Ondanks decennia innovatie in adaptieve immunotherapie stagneert de langetermijn-graftoverleving. Dit commentaar bespreekt hoe de CD47-SIRPα-as de rol van monocyten bij allograaftstoting herkadert.

## English: Giving monocytes their due: how CD47–SIRP-α reframes allograft rejection

This commentary discusses how the CD47-SIRPa axis reframes the understanding of monocyte-mediated allograft rejection. Despite decades of innovation targeting adaptive immunity, long-term graft survival has stagnated, highlighting the overlooked role of innate immune mechanisms in transplant rejection.

## Abstract (original, from the publication)

Despite decades of therapeutic innovation targeting adaptive immunity, such as the development of calcineurin inhibitors and B-cell–depleting agents, like rituximab, long-term graft survival rates have stagnated, with nearly half of allografts failing within 10 years. This enduring challenge underscores a critical oversight in transplant immunology: the predominant focus on adaptive immune responses has largely neglected the role of innate immunity in graft rejection. Historically, rejection was attributed to T- and B-cell recognition of donor major histocompatibility complex (human leukocyte antigen [HLA]) molecules, relegating innate immune cells to a secondary role.

Auteurs: Lennie Messager, Baptiste Lamarthée

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Bron: Kidney International, https://doi.org/https://www.kidney-international.org/article/S0085-2538(25)00877-4/fulltext. Bijgewerkt 2026-07-03T13:25:05Z. Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.