{"id":"ef2254d4a279","type":"article","url":"https://hartvaat.nl/2025/12/03/galectine-1-herprogrammeert-macrofagen-en-moduleert-t-celimmuniteit-bij-atherosc/","title":"Galectine-1 herprogrammeert macrofagen en moduleert T-celimmuniteit bij atherosclerose","title_en":"Galectin-1 induces macrophage immunometabolic reprogramming, modulates T cell immunity and attenuates atherosclerotic plaque formation","category":"cholesterol","category_label":"Cholesterol","professions":[],"tags":[],"journal":"Atherosclerosis","doi":"https://www.atherosclerosis-journal.com/article/S0021-9150(25)01506-0/fulltext","source_url":"https://doi.org/https://www.atherosclerosis-journal.com/article/S0021-9150(25)01506-0/fulltext","authors":["Ya Li","Julian Leberzammer","Xavier Blanchet","Rundan Duan","Michael Lacy","Vasiliki Triantafyllidou","Veit Eckardt","Eva Briem","Anna Simone Jung","Rui Su","Joel Guerra","Yvonne Jansen","Michael Hristov","Wolfgang Enard","Jürgen Bernhagen","Christian Weber","Dorothee Atzler","Alexander Bartelt","Yvonne Döring","Donato Santovito","Herbert Kaltner","Anna-Kristin Ludwig","Philipp von Hundelshausen"],"significance":4,"published":"2025-12-03","source_date":"2025-12-03","image":"","kennis":["https://hartvaat.nl/kennis/lipiden/atherosclerose-pathofysiologie/"],"congress":"","summary_en":"This study demonstrates that galectin-1 induces macrophage immunometabolic reprogramming and modulates T-cell immunity to attenuate atherosclerotic plaque formation, providing mechanistic insight into its anti-atherogenic properties.","created":"2026-07-03T10:25:42Z","updated":"2026-07-03T13:25:05Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Atherosclerose is een chronische immunometabole ziekte. Macrofagen en T-cellen spelen sleutelrollen bij plaque-ontwikkeling. Dit onderzoek toont dat galectine-1 macrofagen immunometabool herprogrammeert en T-celimmuniteit moduleert, wat de plaquevorming vermindert.","abstract_original":"Atherosclerosis is a chronic immunometabolic disease driven by lipid accumulation and immune cell infiltration. Macrophages and T cells play key roles throughout plaque development. Galectin-1 (Gal-1), a glycan-binding protein, modulates immune functions in these cells and has been reported to attenuate atherosclerosis, though its mechanisms remain incompletely understood. Here, we investigated the effects of Gal-1 on macrophages and T cells during plaque formation."}