{"id":"c2219b45ae2a","type":"article","url":"https://hartvaat.nl/2025/12/03/risicoverfijning-in-het-tijdperk-van-een-cac-score-van-nul-de-meerwaarde-van-fit/","title":"Risicoverfijning in het tijdperk van een CAC-score van nul: de meerwaarde van fitheid","title_en":"Refining risk in the power of zero era: The added value of cardiorespiratory fitness","category":"cholesterol","category_label":"Cholesterol","professions":["cardioloog","huisarts"],"tags":["biomarkers-cardiovasculair","calciumscore"],"journal":"Atherosclerosis","doi":"https://www.atherosclerosis-journal.com/article/S0021-9150(25)01505-9/fulltext","source_url":"https://doi.org/https://www.atherosclerosis-journal.com/article/S0021-9150(25)01505-9/fulltext","authors":["Ahmed Ibrahim Ahmed","Mouaz H. Al-Mallah"],"significance":4,"published":"2025-12-03","source_date":"2025-12-03","image":"","kennis":["https://hartvaat.nl/kennis/lipiden/lpa-meten-wanneer-waarom/","https://hartvaat.nl/kennis/preventie/levenslang-cardiovasculair-risico/"],"congress":"","summary_en":"This commentary discusses the added value of cardiorespiratory fitness for cardiovascular risk refinement in patients with a zero coronary artery calcium score, shifting focus from static imaging to functional capacity assessment.","created":"2026-07-03T10:25:42Z","updated":"2026-07-03T13:25:05Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Commentaar bij de studie van Griffin et al. over cardiovasculaire risicostratificatie: van statische beeldvorming naar functionele capaciteit om risico te identificeren bij patiënten met een coronaire calciumscore van nul.","abstract_original":"In this issue of Atherosclerosis, Griffin et al. [1] tackle a key challenge in cardiovascular risk stratification: shifting the focus from static imaging to functional capacity to identify risk in the large population of patients with a zero coronary artery calcification (CAC) score. The authors conducted a cross-sectional analysis of 2322 middle-aged participants from the Swedish CArdioPulmonary bioImage Study (SCAPIS) who had a CAC score of zero. They measured (or, more accurately, estimated) cardiorespiratory fitness (CRF) using a submaximal cycle test and, crucially, used coronary computed tomography angiography (CCTA) to detect the presence of any atherosclerosis."}