{"id":"abe5c318169d","type":"article","url":"https://hartvaat.nl/2025/12/05/hyperactivatie-van-yap-in-podocyten-verstoort-de-rust-van-glomerulaire-cellen/","title":"Hyperactivatie van YAP in podocyten verstoort de rust van glomerulaire cellen","title_en":"When YAP is hyperactivated in podocytes, it persistently “yaps,” disrupting the quiescence of neighboring glomerular cells","category":"chronische nierziekte","category_label":"Nierziekte","professions":["internist"],"tags":[],"journal":"Kidney International","doi":"https://www.kidney-international.org/article/S0085-2538(25)00934-2/fulltext","source_url":"https://doi.org/https://www.kidney-international.org/article/S0085-2538(25)00934-2/fulltext","authors":["Olivia Lenoir","Pierre-Louis Tharaux"],"significance":5,"published":"2025-12-05","source_date":"2025-12-05","image":"","kennis":[],"congress":"","summary_en":"This research demonstrates that hyperactivation of YAP in podocytes disrupts the quiescence of neighbouring glomerular cells, contributing to the pathogenesis of focal segmental glomerulosclerosis and crescentic glomerulonephritis.","created":"2026-07-03T10:25:41Z","updated":"2026-07-03T13:25:05Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Het verlies van glomerulaire epitheelcelrust is kenmerkend voor FSGS en crescentische glomerulonefritis. Dit onderzoek toont dat hyperactivatie van YAP in podocyten persistent de rust van naburige glomerulaire cellen verstoort.","abstract_original":"The loss of glomerular epithelial cell quiescence is a hallmark of focal segmental glomerulosclerosis and crescentic glomerulonephritis (CGN). Still, the pathomechanisms that trigger and drive such events are not fully understood."}