{"id":"464259268c1e","type":"article","url":"https://hartvaat.nl/2025/12/05/hypoxie-responsieve-trna-fragmenten-als-regulatoren-van-rna-autofagie-en-nierbes/","title":"Hypoxie-responsieve tRNA-fragmenten als regulatoren van RNA-autofagie en nierbescherming","title_en":"Small but mighty: hypoxia-responsive tRNA-derived small RNA as a novel regulator of RNA autophagy and kidney protection","category":"chronische nierziekte","category_label":"Nierziekte","professions":[],"tags":[],"journal":"Kidney International","doi":"https://www.kidney-international.org/article/S0085-2538(25)00942-1/fulltext","source_url":"https://doi.org/https://www.kidney-international.org/article/S0085-2538(25)00942-1/fulltext","authors":["Divya Bhatia","Mary E. Choi"],"significance":5,"published":"2025-12-05","source_date":"2025-12-05","image":"","kennis":["https://hartvaat.nl/kennis/cardiometabool/esc-richtlijn-diabetes-cvd-cardiometabool/","https://hartvaat.nl/kennis/nierziekte/kdigo-richtlijn-ckd-2024/"],"congress":"","summary_en":"This study identifies hypoxia-responsive tRNA-derived small RNA fragments as novel regulators of RNA autophagy in kidney cells. The findings reveal a new mechanism of kidney protection through selective RNA recycling during cellular stress.","created":"2026-07-03T10:25:41Z","updated":"2026-07-03T13:25:05Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Autofagie handhaaft cellulaire homeostase en is geactiveerd bij nierziekten. RNA-autofagie is een opkomende afzonderlijke vorm. Dit onderzoek beschrijft hypoxie-responsieve tRNA-fragmenten als nieuwe regulatoren van RNA-autofagie en nierbescherming.","abstract_original":"Autophagy/macroautophagy is well known for maintaining cellular homeostasis and is induced in kidney diseases.1,2 The significance of RNA autophagy, which targets defective RNA via the autophagosome-lysosome pathway, is emerging as a distinct form of selective autophagy that involves RNA recycling. Granulophagy recycles nontranslating mRNA-protein complexes in P-bodies and stress granules, whereas ribophagy targets ribosomes and ribosomal RNA complexes.3 Although RNA autophagy-mediated mRNA degradation and the cytoplasmic degradation pathways, such as canonical decay and the surveillance system, are both capable of clearing defective mRNA, the former has several unique features."}