{"id":"a121dc1a92f3","type":"article","url":"https://hartvaat.nl/2025/12/10/invloed-van-leeftijd-geslacht-en-ras-op-testinterpretatie-bij-primair-aldosteron/","title":"Invloed van leeftijd, geslacht en ras op testinterpretatie bij primair aldosteronisme","title_en":"Impact of Age, Sex, and Race on Primary Aldosteronism Test Interpretations","category":"hypertensie","category_label":"Hypertensie","professions":["huisarts","internist"],"tags":["aldosteronsynthaseremmers","baxdrostat","bloeddrukbehandeling","figaro-dkd","lorundrostat","ras-remmers","resistente-hypertensie","resistente-hypertensie-aldosteronremmers","soul-trial","vrouwen"],"journal":"Hypertension","doi":"https://www.ahajournals.org/doi/abs/10.1161/HYPERTENSIONAHA.125.25855","source_url":"https://doi.org/https://www.ahajournals.org/doi/abs/10.1161/HYPERTENSIONAHA.125.25855","authors":[],"significance":6,"published":"2025-12-10","source_date":"2025-12-10","image":"","kennis":["https://hartvaat.nl/kennis/hypertensie/esc-richtlijn-hypertensie-2024/","https://hartvaat.nl/kennis/preventie/risicofactoren-cardiovasculair/"],"congress":"","summary_en":"This study addressed how age, sex, and race affect the interpretation of primary aldosteronism tests, essential for avoiding misdiagnosis as screening expands to all hypertensive patients under new guidelines.","created":"2026-07-03T10:25:41Z","updated":"2026-07-03T18:38:18Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Nieuwe richtlijnen adviseren testen op primair aldosteronisme bij alle hypertensieve patiënten. Het interpreteren van populatieresultaten vereist begrip van demografische invloeden. Deze studie onderzocht het effect van leeftijd, geslacht en ras op de testinterpretatie.","abstract_original":"Hypertension, Volume 83, Issue 5, Page e25855, May 1, 2026. BACKGROUND:New guidelines recommend testing for primary aldosteronism (PA) in all people with hypertension. Interpreting population-based results for PA will require understanding the influence of demographic characteristics.METHODS:858 adults from across the US meeting traditional guideline criteria for PA testing underwent testing. The influence of demographic factors on test result interpretations was assessed after multivariable adjustment.RESULTS:Mean age was 62±11 years, with 54.6% women, 14% Black, and 22.9% Hispanic. Independent of antihypertensive medications and clinical comorbidities, participants aged ≥70 years had 24% lower aldosterone (P<0.05), 48% lower renin activity (P<0.001), and trended toward higher aldosterone-to-renin ratio (52% higher;P=0.14), compared with those <50 years. Aldosterone levels were higher in women compared with men across the lifespan. Black participants had 81% highe"}