{"id":"3221113f30ad","type":"article","url":"https://hartvaat.nl/2025/12/11/ticagrelor-plus-aspirine-versus-aspirine-na-cabg-voor-acs-gerandomiseerde-trial/","title":"Ticagrelor plus aspirine versus aspirine na CABG voor ACS: gerandomiseerde trial","title_en":"Ticagrelor and Aspirin or Aspirin Alone after Coronary Surgery for Acute Coronary Syndrome.","category":"algemeen","category_label":"Algemeen","professions":["apotheker","cardioloog"],"tags":[],"journal":"The New England journal of medicine","doi":"10.1056/NEJMoa2508026","source_url":"https://doi.org/10.1056/NEJMoa2508026","authors":["Anders Jeppsson","Stefan James","Christian H Moller","Carl Johan Malm","Magnus Dalén","Farkas Vanky","Ivy Susanne Modrau","Karl Andersen","Vesa Anttila","Gennady V Atroshchenko","Mikael Barbu","Mats Dreifaldt","Ali Imad El-Akkawi","Örjan Friberg","Tomas Gudbjartsson","Jarmo Gunn","Rune Haaverstad","Jari Halonen","Emma C Hansson","Jonas Holm","Annastiina Husso","Tatu Juvonen","Øyvind Jakobsen","Lena Jideus","Emilia Johannesson","Anna Jonsson Holmdahl","Kristjan Jonsson","Solveig Moss Kolseth","Lytfi Krasniqi","Tuomas Mäkelä","Ari Mennander","Lars-Erik Mohagen Krogstad","Sulman Rafiq","Peter Raivio","Lars Riber","Aminah Tahir","Carl Thorsen","Theis Tønnessen","Alexander Wahba","Igor Zindovic","Aldina Pivodic","Susanne J Nielsen","David Erlinge","Joakim Alfredsson","Ulrik Sartipy"],"significance":7,"published":"2025-12-11","source_date":"2025-12-11","image":"","kennis":["https://hartvaat.nl/kennis/coronairlijden/cabg-bypasschirurgie/","https://hartvaat.nl/kennis/coronairlijden/pci-vs-cabg-afweging/"],"congress":"","summary_en":"This NEJM trial investigated whether adding ticagrelor to aspirin after CABG for ACS improves outcomes compared with aspirin alone, addressing the optimal antiplatelet strategy in the post-surgical setting.","created":"2026-07-03T10:32:04Z","updated":"2026-07-03T13:31:02Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Trial onderzocht of ticagrelor plus aspirine beter is dan aspirine alleen na CABG voor ACS. De resultaten informeren het antiplaatjesbeleid na chirurgische revascularisatie.","abstract_original":"BACKGROUND: Patients benefit from antiplatelet therapy after coronary-artery bypass grafting (CABG) for an acute coronary syndrome. Whether the addition of ticagrelor to aspirin, as compared with aspirin alone, further reduces the risk of adverse cardiovascular outcomes is unclear. METHODS: In this open-label, registry-based, clinical trial conducted at 22 Nordic cardiothoracic surgery centers, we randomly assigned patients in a 1:1 ratio to receive either ticagrelor plus aspirin or aspirin alone for 1 year after CABG for an acute coronary syndrome. The primary outcome was a composite of death, myocardial infarction, stroke, or repeat revascularization, evaluated at 1 year. A key secondary outcome was net adverse clinical events, defined as a primary-outcome event or major bleeding. RESULTS: A total of 2201 patients were randomly assigned to receive ticagrelor plus aspirin (1104 patients) or aspirin alone (1097 patients). The mean age of the patients was 66 years, and 14.4% were women. A primary-outcome event occurred in 53 patients (4.8%) in the ticagrelor-plus-aspirin group and 50 (4.6%) in the aspirin-alone group (hazard ratio, 1.06; 95% confidence interval [CI], 0.72 to 1.56; P = 0.77). Net adverse clinical events occurred in 9.1% of patients in the ticagrelor-plus-aspirin group and 6.4% in the aspirin-alone group (hazard ratio, 1.45; 95% CI, 1.07 to 1.97). Major bleeding occurred in 4.9% of patients in the ticagrelor-plus-aspirin group and 2.0% in the aspirin-alone group (hazard ratio, 2.50; 95% CI, 1.52 to 4.11). CONCLUSIONS: Among patients who underwent CABG for an acute coronary syndrome, ticagrelor plus aspirin did not result in a lower incidence of death, myocardial infarction, stroke, or repeat coronary revascularization than aspirin alone at 1 year. (Funded by the Swedish Research Council and others; TACSI ClinicalTrials.gov number, NCT03560310; EudraCT number, 2017-001499-43; EU Clinical Trials number, 2023-508551-40-00.)."}