{"id":"1ae28105c8a0","type":"article","url":"https://hartvaat.nl/2025/12/15/aldh1a1-reguleert-pd-l1-transcriptie-combinatietherapie-bij-adpkd/","title":"ALDH1A1 reguleert PD-L1-transcriptie: combinatietherapie bij ADPKD","title_en":"Aldehyde dehydrogenase 1 A1 regulates the transcription of PD-L1 and its targeting with disulfiram together with PD-L1 immunotherapy synergistically delays cyst growth in ADPKD","category":"chronische nierziekte","category_label":"Nierziekte","professions":["internist"],"tags":[],"journal":"Kidney International","doi":"https://www.kidney-international.org/article/S0085-2538(25)00988-3/fulltext","source_url":"https://doi.org/https://www.kidney-international.org/article/S0085-2538(25)00988-3/fulltext","authors":["Alice Shasha Cheng","Linda Xiaoyan Li","Julie Xia Zhou","Peter C. Harris","James P. Calvet","Xiaogang Li"],"significance":5,"published":"2025-12-15","source_date":"2025-12-15","image":"","kennis":["https://hartvaat.nl/kennis/nierziekte/diabetische-nefropathie/"],"congress":"","summary_en":"This study demonstrates that aldehyde dehydrogenase 1A1 regulates PD-L1 transcription in autosomal dominant polycystic kidney disease. Combination therapy with disulfiram and PD-L1 immunotherapy synergistically delayed cyst growth, offering a novel therapeutic approach.","created":"2026-07-03T10:25:41Z","updated":"2026-07-03T13:25:04Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"ADPKD is de meest voorkomende erfelijke nierziekte zonder effectieve therapie. Dit onderzoek toont dat ALDH1A1 de PD-L1-expressie reguleert en dat disulfiram gecombineerd met PD-L1-immunotherapie de cystegroei synergistisch vertraagt.","abstract_original":"Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the most common inherited kidney disease with no effective therapy to halt its progression. ALDH1A1, one of the aldehyde dehydrogenases, is the main ALDH1 isozyme known to oxidize 9-cis retinaldehyde into 9-cis retinoic acid, which can regulate the expression of the PKD1 gene. However, the role and mechanisms of ALDH1A1 in ADPKD remains elusive."}