{"id":"8357bd524186","type":"article","url":"https://hartvaat.nl/2025/12/15/enkelvoudige-pil-combinatietherapie-bij-hypertensie-aha-wetenschappelijk-stateme/","title":"Enkelvoudige-pil combinatietherapie bij hypertensie: AHA-wetenschappelijk statement","title_en":"Single-Pill Combination Therapy for the Management of Hypertension: A Scientific Statement From the American Heart Association","category":"hypertensie","category_label":"Hypertensie","professions":["apotheker","cardioloog","huisarts","internist"],"tags":["acuut-hartfalen","bloeddrukbehandeling","cardio-renaal-metabool","ras-remmers","renale-denervatie","sacubitril-valsartan","slaapapneu","vrouwen"],"journal":"Hypertension","doi":"https://www.ahajournals.org/doi/abs/10.1161/HYP.0000000000000258","source_url":"https://doi.org/https://www.ahajournals.org/doi/abs/10.1161/HYP.0000000000000258","authors":[],"significance":7,"published":"2025-12-15","source_date":"2025-12-15","image":"","kennis":["https://hartvaat.nl/kennis/hypertensie/hypertensie-en-ckd/","https://hartvaat.nl/kennis/hypertensie/resistente-hypertensie/"],"congress":"","summary_en":"This AHA scientific statement on single-pill combination therapy for hypertension reviewed the evidence supporting fixed-dose combinations as the preferred approach for improving blood pressure control at the population level.","created":"2026-07-03T10:25:40Z","updated":"2026-07-03T18:38:18Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"De groeiende wereldwijde hypertensielast en onvoldoende bloeddrukcontrole vragen om effectieve strategieën. Dit AHA-statement bespreekt de wetenschappelijke basis voor enkelvoudige-pil combinatietherapie als benadering om de bloeddrukbehandeling te optimaliseren.","abstract_original":"Hypertension, Volume 83, Issue 3, Page e00258, March 1, 2026. The growing global burden of hypertension and inadequate blood pressure control necessitate effective therapeutic strategies to improve blood pressure management and reduce the risks of cardiovascular diseases attributable to hypertension. Single-pill combination medications for hypertension combine ≥2 antihypertensive agents in a single tablet. Single-pill combination medications offer a promising opportunity to achieve faster and more sustained blood pressure control compared with stepped care (ie, prescribing antihypertensive monotherapy, titrating the dose, and later adding more antihypertensive agents). Single-pill combination medications combine complementary mechanisms of action of antihypertensive agents to more effectively lower blood pressure while reducing adverse effects. This approach simplifies treatment regimens by lowering pill burden, improves patient adherence, overcomes clinician inertia by simplifying pre"}