{"id":"c58f3def2278","type":"article","url":"https://hartvaat.nl/2025/12/15/m7g-methyltransferase-mettl1-bevordert-acuut-nierletsel-via-mitochondriale-disfu/","title":"m7G-methyltransferase METTL1 bevordert acuut nierletsel via mitochondriale disfunctie","title_en":"The m7G methyltransferase METTL1 promotes acute kidney inflammation by disrupting mitochondrial function","category":"chronische nierziekte","category_label":"Nierziekte","professions":["internist"],"tags":[],"journal":"Kidney International","doi":"https://www.kidney-international.org/article/S0085-2538(25)00990-1/fulltext","source_url":"https://doi.org/https://www.kidney-international.org/article/S0085-2538(25)00990-1/fulltext","authors":["Shuai-shuai Xie","Yu-hang Dong","Jian Gao","Wei Li","Long Xu","Jia-nan Wang","Ju-tao Yu","Chao Hou","Chao Li","Ying-ying Gao","Ze-hui Dong","Wen-xian Ma","Rui Hou","Shuai Sun","Ming-lu Ji","Ruo-bing He","Xiao-guo Suo","Wei-jian Ni","Jia-gen Wen","Juan Jin","Qin Yang","Hong Cai","Xiao-ming Meng"],"significance":5,"published":"2025-12-15","source_date":"2025-12-15","image":"","kennis":["https://hartvaat.nl/kennis/cardiometabool/obesitas-en-hart/"],"congress":"","summary_en":"This research reveals that the m7G methyltransferase METTL1 promotes acute kidney inflammation by disrupting mitochondrial function. The findings identify a new RNA modification-mediated pathway in acute kidney injury pathogenesis.","created":"2026-07-03T10:25:40Z","updated":"2026-07-03T13:25:04Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"RNA-modificaties reguleren inflammatoire ziekten. De rol van N7-methylguanosine en het enzym METTL1 bij inflammatoire nierziekten was onbekend. Dit onderzoek toont dat METTL1 acute nierontsteking bevordert door mitochondriale functieverstoring.","abstract_original":"RNA modifications regulate the progression of inflammatory diseases. However, the role of N7-methylguanosine (m7G) modification and its regulatory enzyme, methyltransferase-like 1 (METTL1), in inflammatory kidney diseases remains poorly understood. Here, we aimed to investigate the function and underlying mechanisms of METTL1-mediated m7G modification in acute kidney injury (AKI)."}