{"id":"cc654a6760d0","type":"article","url":"https://hartvaat.nl/2025/12/18/bradycardie-bij-topsporters-prevalentie-mechanismen-en-risico-s/","title":"Bradycardie bij topsporters: prevalentie, mechanismen en risico's","title_en":"Bradycardia in Athletes: Prevalence, Mechanisms, and Risks","category":"algemeen","category_label":"Algemeen","professions":["cardioloog","huisarts"],"tags":["bradycardie"],"journal":"Circulation","doi":"https://www.ahajournals.org/doi/abs/10.1161/CIRCULATIONAHA.125.076170","source_url":"https://doi.org/https://www.ahajournals.org/doi/abs/10.1161/CIRCULATIONAHA.125.076170","authors":[],"significance":7,"published":"2025-12-18","source_date":"2025-12-18","image":"","kennis":["https://hartvaat.nl/kennis/ritmestoornissen/sport-en-ritmestoornissen/","https://hartvaat.nl/kennis/diagnostiek/inspanningstest-loopband-fiets/"],"congress":"","summary_en":"This study from the Pro@Heart cohort characterized bradycardia in endurance athletes using comprehensive imaging and monitoring, exploring the genetic and physiological mechanisms of sinus node remodeling and distinguishing benign athletic adaptation from pathological conduction disease.","created":"2026-07-03T10:25:07Z","updated":"2026-07-03T13:24:34Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"In het Pro@Heart-cohort werden topsporters uitgebreid onderzocht met beeldvorming, inspanningstests en Holtermonitoring. Genetische aanleg voor bradycardie werd beoordeeld met een gevalideerde polygene risicoscore, wat nieuwe inzichten oplevert over de genetische bijdrage aan sportbradycardie.","abstract_original":"BACKGROUND:Sinus bradycardia is a well-recognized physiological adaptation in endurance athletes, primarily attributed to sinus node remodeling or increased vagal modulation. Although genetic influences on resting heart rate (HR) have been observed, the genetic contribution to athletic bradycardia has not been elucidated.METHODS:We phenotyped current and former elite endurance athletes in the Pro@Heart cohort study using multimodal cardiac imaging, cardiopulmonary exercise testing, and Holter monitoring. Genetic susceptibility to bradycardia was assessed using a validated HR-associated polygenic risk score (HR-PRS), in which lower scores are associated with a lower HR, and compared with healthy nonathletic controls. Clinical and genetic features of bradycardic endurance athletes with minimum HR ≤40 bpm on a Holter monitor (bradycardic athletes [BAs]) were compared with non-BAs). A healthy cohort of nonathletes from the ASPREE study (Aspirin in Reducing Events in the Elderly) were used "}