{"id":"ae6af30bcc92","type":"article","url":"https://hartvaat.nl/2025/12/22/complementactivatie-drijft-compartiment-specifieke-immuunrespons-bij-c3-glomerul/","title":"Complementactivatie drijft compartiment-specifieke immuunrespons bij C3-glomerulopathie","title_en":"Complement activation drives a compartmentalized innate immune response in C3 glomerulopathy contributing to the disease phenotype","category":"chronische nierziekte","category_label":"Nierziekte","professions":["internist"],"tags":["cystatine-c","iga-nefropathie"],"journal":"Kidney International","doi":"https://www.kidney-international.org/article/S0085-2538(25)01012-9/fulltext","source_url":"https://doi.org/https://www.kidney-international.org/article/S0085-2538(25)01012-9/fulltext","authors":["Marie-Sophie Meuleman","Aurélien de Reyniès","Céline Mayinga","Stéphanie Ngo","Nathalie Rioux-Leclercq","Agathe Vermorel","Jérome Olagne","Diane Giovannini","Arnaud Francois","Anne Croué","Gaëtane Planchard","David Buob","Yahsou Delmas","Marie Courbebaisse","Béatrice Parfait","David Lebeaux","Gérard Friedlander","Marina Avramescu","Benoit Brilland","Hugoline Boulay","Manon Martins","Lubka Roumenina","Véronique Frémeaux-Bacchi","Jean-Paul Duong Van Huyen","Sophie Chauvet"],"significance":6,"published":"2025-12-22","source_date":"2025-12-22","image":"","kennis":["https://hartvaat.nl/kennis/cardiometabool/esc-richtlijn-diabetes-cvd-cardiometabool/"],"congress":"","summary_en":"This study characterized how complement activation drives compartmentalized innate immune responses in C3 glomerulopathy, advancing the understanding of complement-mediated kidney disease pathophysiology.","created":"2026-07-03T10:25:39Z","updated":"2026-07-03T13:25:03Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"C3-glomerulopathie is een zeldzame nierziekte door dysregulatie van de complementalternatieve route. De mechanistische diversiteit en heterogene profielen bemoeilijken een volledig begrip. Deze studie beschrijft de compartiment-specifieke immuunrespons.","abstract_original":"C3 glomerulopathy is a rare kidney disease resulting from dysregulation of the complement alternative pathway. The mechanistic diversity of alternative pathway activation, the heterogeneous immunological and clinical profiles limit a comprehensive understanding of the disease."}