{"id":"9d46f694cd44","type":"article","url":"https://hartvaat.nl/2025/12/23/plasma-proteomische-biomarkers-voor-risico-en-therapeutische-doelen-bij-abdomina/","title":"Plasma-proteomische biomarkers voor risico en therapeutische doelen bij abdominaal aorta-aneurysma","title_en":"Identifying plasma proteomic biomarkers for risk prediction and therapeutic targets of abdominal aortic aneurysm: Prospective cohort and Mendelian randomization analyses","category":"cholesterol","category_label":"Cholesterol","professions":["cardioloog","internist"],"tags":["aorta-aneurysma","lipoproteïne-a-therapeutisch-doel"],"journal":"Atherosclerosis","doi":"https://www.atherosclerosis-journal.com/article/S0021-9150(25)01522-9/fulltext","source_url":"https://doi.org/https://www.atherosclerosis-journal.com/article/S0021-9150(25)01522-9/fulltext","authors":["Yanjun Zhang","Yu Huang","Xiaoqin Gan","Ziliang Ye","Yuanyuan Zhang","Sisi Yang","Hao Xiang","Yiwei Zhang","Yiting Wu","Xianhui Qin"],"significance":5,"published":"2025-12-23","source_date":"2025-12-23","image":"","kennis":[],"congress":"","summary_en":"Using prospective cohort data and Mendelian randomisation, this study identified plasma proteomic biomarkers associated with abdominal aortic aneurysm risk. The findings provide potential targets for AAA risk prediction and pharmacological intervention.","created":"2026-07-03T10:25:39Z","updated":"2026-07-03T13:25:02Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Abdominaal aorta-aneurysma (AAA) mist betrouwbare circulerende biomarkers en effectieve farmacotherapie. Via prospectief cohortonderzoek en Mendeliaanse randomisatie werden observationele en causale associaties tussen plasma-eiwitten en AAA onderzocht.","abstract_original":"Abdominal aortic aneurysm (AAA) lacks reliable circulating biomarkers and effective pharmacological therapies. This study aimed to investigate the observational and causal associations between plasma proteins and AAA to enhance understanding of its biological mechanisms, improve disease prediction, and identify potential therapeutic targets."}