{"id":"9cb73c022f34","type":"article","url":"https://hartvaat.nl/2025/12/23/sglt2-remming-verbetert-leeftijdsafhankelijke-microvasculaire-rarefactie-van-de-/","title":"SGLT2-remming verbetert leeftijdsafhankelijke microvasculaire rarefactie van de nier","title_en":"Sodium-glucose co-transporter 2 inhibition improves age-dependent kidney microvascular rarefaction","category":"chronische nierziekte","category_label":"Nierziekte","professions":["apotheker","internist"],"tags":["canagliflozine","empagliflozine","perifeer-vaatlijden","sglt2-remmers"],"journal":"Kidney International","doi":"https://www.kidney-international.org/article/S0085-2538(25)01020-8/fulltext","source_url":"https://doi.org/https://www.kidney-international.org/article/S0085-2538(25)01020-8/fulltext","authors":["Anastasia Paulmann","Matthew D. Cox","Tom Boewer","Hannah M. Somers","Heath Fuqua","Ryan P. Seaman","Joel H. Graber","Anchal Mahajan","Cory P. Johnson","Laura L. Beverly-Staggs","Sonia Sandhi","Heiko Schenk","Hermann Haller"],"significance":5,"published":"2025-12-23","source_date":"2025-12-23","image":"","kennis":["https://hartvaat.nl/kennis/nierziekte/sglt2-nierbescherming-mechanisme/"],"congress":"","summary_en":"This research demonstrates that SGLT2 inhibition improves age-dependent microvascular rarefaction in the kidney. The findings suggest a novel mechanism by which SGLT2 inhibitors may protect against age-related decline in kidney function and vascular structure.","created":"2026-07-03T10:25:39Z","updated":"2026-07-03T13:25:02Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Veroudering gaat gepaard met progressief verlies van nierfunctie en vaatstructuur. De mechanismen zijn onvoldoende begrepen. Dit onderzoek toont dat SGLT2-remming de leeftijdsafhankelijke microvasculaire rarefactie in de nier verbetert.","abstract_original":"Aging is associated with progressive loss of kidney function and vascular structure, with and without chronic kidney disease. However, the mechanisms driving kidney vascular aging and potential therapeutic interventions remain poorly understood."}