# Gemodificeerde regulatoire T-lymfocyten bevorderen herstel van het geïnfarceerde hart

*geplaatst 2025-12-29 · Algemeen · Circulation · doi https://www.ahajournals.org/doi/abs/10.1161/CIRCULATIONAHA.125.076321 · https://hartvaat.nl/2025/12/29/gemodificeerde-regulatoire-t-lymfocyten-bevorderen-herstel-van-het-geinfarceerde/*

Myocardinfarct veroorzaakt een ontregeld genezingsproces met overmatige fibrose en onopgeloste inflammatie. Regulatoire T-lymfocyten moduleren dit proces. Dit onderzoek toont dat gemodificeerde Tregs het hartinfarct-herstel bevorderen.

## English: Engineered Regulatory T Lymphocytes Promote Infarcted Heart Repair

This study demonstrated that engineered regulatory T lymphocytes can promote repair of infarcted myocardium by resolving inflammation and reducing fibrosis, advancing cell-based immunomodulation as a regenerative cardiac therapy approach.

## Abstract (original, from the publication)

BACKGROUND:Myocardial infarction (MI) initiates a dysregulated healing process characterized by excessive fibrosis and unresolved inflammation, resulting in suboptimal cardiac repair in clinical settings. Regulatory T lymphocytes (Tregs) naturally orchestrate cardiac repair after MI, but their therapeutic potential is limited by inefficient homing to ischemic myocardium. We hypothesize that FAP (fibroblast activation protein)–specific CAR (chimeric antigen receptor) engineering overcomes this barrier by enabling precise delivery of Tregs to FAP⁺-enriched infarct zones, thereby focally amplifying reparative activity within injured myocardium.METHODS:In murine MI and ischemia–reperfusion models, C57BL/6J mice were injected with lentivirus-engineered FAP CAR Tregs (FCTRs) or mock Tregs derived from wild-type, IL-10 (interleukin-10) knockout (IL-10−/−) or Areg (amphiregulin) knockout (Areg−/−) donors after infarction. The cardiac outcomes and underlying mechanisms mediated by FCTRs were th

Auteurs: Min Zhang

---
Bron: Circulation, https://doi.org/https://www.ahajournals.org/doi/abs/10.1161/CIRCULATIONAHA.125.076321. Bijgewerkt 2026-07-03T18:38:17Z. Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.