# Overgang van AKI naar CKD: rol van niermacrofagen en neutrofielen

*geplaatst 2025-12-30 · Nierziekte · Kidney International · doi https://www.kidney-international.org/article/S0085-2538(25)01028-2/fulltext · https://hartvaat.nl/2025/12/30/overgang-van-aki-naar-ckd-rol-van-niermacrofagen-en-neutrofielen/*

CKD treft 15% van de volwassenen wereldwijd. De overgang van acuut nierletsel naar chronische nierziekte is een cruciaal proces. Dit overzicht bespreekt de rol van nierresidente macrofagen en neutrofielen als therapeutische doelwitten.

## English: Key drivers and potential therapeutic targets in the AKI-to-CKD transition: roles of kidney-resident macrophages and neutrophils

This review discusses the key drivers of the AKI-to-CKD transition, focusing on kidney-resident macrophages and neutrophils as potential therapeutic targets. Understanding innate immune mechanisms in maladaptive repair may identify new interventions to prevent CKD progression.

## Abstract (original, from the publication)

Chronic kidney disease (CKD), characterized by irreversible kidney damage and a decline in kidney function for at least 3 months, affects 15% of adults worldwide and is tightly linked to kidney failure, cardiovascular disease, mental disorders, and heightened susceptibility to infections. Acute kidney injury (AKI) occurs in 23% of hospitalized patients, is associated with in-hospital mortality,1 and predisposes patients to CKD.2 After AKI, proximal tubular cells (PTCs) fail to repair through multifaceted mechanisms, including cell cycle arrest at the G2/M phase, maladaptive dedifferentiation (i.e., partial epithelial-mesenchymal transition or epithelial cell plasticity), mitochondrial dysfunction, and epigenetic alteration.

Auteurs: Kensei Taguchi, Kei Fukami

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Bron: Kidney International, https://doi.org/https://www.kidney-international.org/article/S0085-2538(25)01028-2/fulltext. Bijgewerkt 2026-07-03T13:25:01Z. Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.