{"id":"b2179d56e197","type":"article","url":"https://hartvaat.nl/2025/12/30/transcriptanalyse-van-langdurige-varken-naar-primaat-nierxenograften/","title":"Transcriptanalyse van langdurige varken-naar-primaat nierxenograften","title_en":"Mechanistic insights from transcript analysis of long-term pig to non-human primate kidney xenografts","category":"chronische nierziekte","category_label":"Nierziekte","professions":["internist"],"tags":[],"journal":"Kidney International","doi":"https://www.kidney-international.org/article/S0085-2538(25)01008-7/fulltext","source_url":"https://doi.org/https://www.kidney-international.org/article/S0085-2538(25)01008-7/fulltext","authors":["Ivy A. Rosales","Alessia Giarraputo","Claire Trivin-Avillach","Ahmad Karadagi","Christina Laguerre","Toru Goto","Jeremy Marcin","Nicole Brousaides","Tatsuo Kawai","Robert B. Colvin"],"significance":5,"published":"2025-12-30","source_date":"2025-12-30","image":"","kennis":[],"congress":"","summary_en":"Transcript analysis of long-term porcine kidney xenografts in non-human primates achieving up to two years of survival revealed distinct molecular mechanisms compared with allografts. The insights inform the development of xenotransplantation for future organ shortage solutions.","created":"2026-07-03T10:25:37Z","updated":"2026-07-03T13:25:01Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Varkensxenograften zijn een potentiële toekomstige orgaanbron. Korte klinische studies suggereerden andere mechanismen dan bij allograften. Deze studie biedt inzichten vanuit transcriptanalyse van langdurige xenograften bij niet-humane primaten.","abstract_original":"Porcine xenografts are a potential future organ source. Limited short-term clinical studies have suggested different mechanisms in xenografts than allografts. Here, we sought further insights from transcript analysis of xenografts in non-human primates that achieved up to two years of survival."}