{"id":"50b2f864fac7","type":"article","url":"https://hartvaat.nl/2026/01/01/consistentie-van-bloeddrukrespons-op-kaliumverrijkt-zout-ssass-subanalyse/","title":"Consistentie van bloeddrukrespons op kaliumverrijkt zout: SSaSS subanalyse","title_en":"Consistency of Blood Pressure Response to Potassium-Enriched Salt in the China Salt Substitute Study.","category":"hypertensie","category_label":"Hypertensie","professions":["cardioloog","huisarts"],"tags":[],"journal":"Hypertension (Dallas, Tex. : 1979)","doi":"10.1161/HYPERTENSIONAHA.125.24723","source_url":"https://doi.org/10.1161/HYPERTENSIONAHA.125.24723","authors":["Katrina Kissock","Bruce Neal","Yifang Yuan","Johan Sundström","Helena Jonsson","Anthony Rodgers","Nelson Wang","Liping Huang","Yangfeng Wu"],"significance":6,"published":"2026-01-01","source_date":"2026-01-01","image":"","kennis":[],"congress":"","summary_en":"This SSaSS subanalysis confirmed a consistent blood pressure-lowering response to potassium-enriched salt across all demographic and clinical subgroups, supporting universal applicability of the salt substitution strategy.","created":"2026-07-03T10:32:05Z","updated":"2026-07-03T13:31:04Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"SSaSS subanalyse bevestigde een consistente bloeddrukrespons op kaliumverrijkt zout over alle subgroepen. De interventie is universeel toepasbaar.","abstract_original":"BACKGROUND: Large between-person differences in blood pressure (BP) responses to sodium reduction, potassium supplementation, and potassium-enriched salt have been suggested by prior studies. However, limitations in research designs and misinterpretation of findings mean that overestimation of true between-person variation in response is likely. METHODS: Systolic BP (SBP) response during a 4-week run-in period on potassium-enriched salt was measured for 608 individuals. Participants were defined as apparently sensitive if SBP fell and apparently resistant if SBP was unchanged or rose. The effect of potassium-enriched salt compared with regular salt on SBP was then compared for apparently sensitive versus apparently resistant groups over a subsequent 12-month postrandomization period. A linear mixed model was used to determine how background within-person BP variability contributed to apparent between-person differences in BP response. RESULTS: Apparent between-person variability in SBP response during run-in was substantial (mean SBP response, -13.7 [SD, 19.3; range, -80 to +56.5] mm Hg). Run-in identified 477 individuals as apparently sensitive and 131 as apparently resistant. Mean effects on SBP of potassium-enriched salt compared with regular salt over 12 months post-randomization were -2.2 mm Hg for apparently sensitive and -7.2 mm Hg for apparently resistant individuals, with no difference between the 2 groups (P=0.068). The mixed models identified no contribution of apparent run-in sensitivity to the observed between-person differences in postrandomization BP responses to potassium-enriched salt. CONCLUSIONS: Individuals classified as responsive or resistant to potassium-enriched salt during initial exposure did not differ in their response to subsequent exposure. REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT00145756."}