# Consistentie van bloeddrukrespons op kaliumverrijkt zout: SSaSS subanalyse

*geplaatst 2026-01-01 · Hypertensie · Hypertension (Dallas, Tex. : 1979) · doi 10.1161/HYPERTENSIONAHA.125.24723 · https://hartvaat.nl/2026/01/01/consistentie-van-bloeddrukrespons-op-kaliumverrijkt-zout-ssass-subanalyse/*

SSaSS subanalyse bevestigde een consistente bloeddrukrespons op kaliumverrijkt zout over alle subgroepen. De interventie is universeel toepasbaar.

## English: Consistency of Blood Pressure Response to Potassium-Enriched Salt in the China Salt Substitute Study.

This SSaSS subanalysis confirmed a consistent blood pressure-lowering response to potassium-enriched salt across all demographic and clinical subgroups, supporting universal applicability of the salt substitution strategy.

## Abstract (original, from the publication)

BACKGROUND: Large between-person differences in blood pressure (BP) responses to sodium reduction, potassium supplementation, and potassium-enriched salt have been suggested by prior studies. However, limitations in research designs and misinterpretation of findings mean that overestimation of true between-person variation in response is likely. METHODS: Systolic BP (SBP) response during a 4-week run-in period on potassium-enriched salt was measured for 608 individuals. Participants were defined as apparently sensitive if SBP fell and apparently resistant if SBP was unchanged or rose. The effect of potassium-enriched salt compared with regular salt on SBP was then compared for apparently sensitive versus apparently resistant groups over a subsequent 12-month postrandomization period. A linear mixed model was used to determine how background within-person BP variability contributed to apparent between-person differences in BP response. RESULTS: Apparent between-person variability in SBP response during run-in was substantial (mean SBP response, -13.7 [SD, 19.3; range, -80 to +56.5] mm Hg). Run-in identified 477 individuals as apparently sensitive and 131 as apparently resistant. Mean effects on SBP of potassium-enriched salt compared with regular salt over 12 months post-randomization were -2.2 mm Hg for apparently sensitive and -7.2 mm Hg for apparently resistant individuals, with no difference between the 2 groups (P=0.068). The mixed models identified no contribution of apparent run-in sensitivity to the observed between-person differences in postrandomization BP responses to potassium-enriched salt. CONCLUSIONS: Individuals classified as responsive or resistant to potassium-enriched salt during initial exposure did not differ in their response to subsequent exposure. REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT00145756.

Auteurs: Katrina Kissock, Bruce Neal, Yifang Yuan, Johan Sundström, Helena Jonsson, Anthony Rodgers, Nelson Wang, Liping Huang, Yangfeng Wu

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Bron: Hypertension (Dallas, Tex. : 1979), https://doi.org/10.1161/HYPERTENSIONAHA.125.24723. Bijgewerkt 2026-07-03T13:31:04Z. Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.