{"id":"8aa8446cfcbd","type":"article","url":"https://hartvaat.nl/2026/01/01/metabole-score-voor-visceraal-vet-en-risico-op-perifeer-arterieel-vaatlijden-bij/","title":"Metabole score voor visceraal vet en risico op perifeer arterieel vaatlijden bij hypertensie","title_en":"The metabolic score for visceral fat and risk of peripheral arterial disease in hypertension patients: a prospective cohort study.","category":"hypertensie","category_label":"Hypertensie","professions":["huisarts","internist"],"tags":["diabetes-en-hart","obesitas","perifeer-vaatlijden","voeding-hart"],"journal":"Frontiers in endocrinology","doi":"10.3389/fendo.2026.1764481","source_url":"https://doi.org/10.3389/fendo.2026.1764481","authors":["Shiping Li","Congcong Yan","Meihui Wu","Tao Wang","Lingjuan Zhu","Chao Yu","Weifang Zhang","Wei Zhou","Huihui Bao","Xiaoshu Cheng"],"significance":3,"published":"2026-01-01","source_date":"2026-01-01","image":"https://hartvaat.nl/global/img/f9ed94fb64aa.webp","kennis":["https://hartvaat.nl/kennis/nierziekte/nierziekte-en-cardiovasculair-risico/","https://hartvaat.nl/kennis/hypertensie/hypertensie-en-ckd/"],"congress":"","summary_en":"A prospective cohort study demonstrated that the Metabolic Score for Visceral Fat is associated with increased risk of peripheral artery disease in hypertensive patients, supporting this novel adiposity metric as a cardiovascular risk marker.","created":"2026-07-03T10:25:36Z","updated":"2026-07-03T13:25:00Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"De Metabolic Score for Visceral Fat (METS-VF) correleert met verhoogd cardiovasculair risico. Deze prospectieve cohortstudie onderzocht het verband tussen METS-VF en het risico op perifeer arterieel vaatlijden bij hypertensieve patiënten.","abstract_original":"BACKGROUND: The Metabolic Score for Visceral Fat (METS - VF), a novel metric for evaluating visceral adipose tissue, has been demonstrated to exhibit a significant correlation with an elevated cardiovascular risk. Nevertheless, its relationship with peripheral artery disease (PAD) remains ambiguous. Consequently, the present study aimed to explore the association between METS-VF and PAD. METHODS AND RESULTS: This prospective study was based on a Chinese H-type hypertension cohort, comprising 6,452 patients. The association between METS-VF and PAD was evaluated using the Cox proportional hazards regression analysis and the method of restricted cubic splines (RCS). During an median follow-up time of 3.9 years, 266 PAD events occurred. The mean age of all participants was 63.20 ± 8.38 years. In the fully adjusted model, each 1-unit increase of METS-VF raised the risk of PAD by 21.0% (HR = 1.21, 95%CI: 1.07, 1.37). There was a saturation effect of METS-VF with an inflection point of 8.63 on PAD. For METS-VF < 8.63, each unit increase was associated with a 69.0% higher risk of PAD (HR=1.69, 95%CI: 1.32-2.16), while for METS-VF ≥8.63, there was no significant association between them (HR=0.93, 95%CI: 0.73-1.19) (P for log-likelihood ratio test= 0.002). Subgroup analysis further showed a significant interaction between METS-VF and current smoking status (P for interaction<0.05), with a stronger association observed in non-smokers. CONCLUSION: METS-VF exhibited a saturation effect on PAD in hypertensive adults in China. Increased METS-VF was positively associated with a higher risk of PAD among hypertensive adults with METS-VF < 8.63, and this association was more pronounced in non-smokers."}