# Metabole score voor visceraal vet en risico op perifeer arterieel vaatlijden bij hypertensie

*geplaatst 2026-01-01 · Hypertensie · Frontiers in endocrinology · doi 10.3389/fendo.2026.1764481 · https://hartvaat.nl/2026/01/01/metabole-score-voor-visceraal-vet-en-risico-op-perifeer-arterieel-vaatlijden-bij/*

De Metabolic Score for Visceral Fat (METS-VF) correleert met verhoogd cardiovasculair risico. Deze prospectieve cohortstudie onderzocht het verband tussen METS-VF en het risico op perifeer arterieel vaatlijden bij hypertensieve patiënten.

## English: The metabolic score for visceral fat and risk of peripheral arterial disease in hypertension patients: a prospective cohort study.

A prospective cohort study demonstrated that the Metabolic Score for Visceral Fat is associated with increased risk of peripheral artery disease in hypertensive patients, supporting this novel adiposity metric as a cardiovascular risk marker.

## Abstract (original, from the publication)

BACKGROUND: The Metabolic Score for Visceral Fat (METS - VF), a novel metric for evaluating visceral adipose tissue, has been demonstrated to exhibit a significant correlation with an elevated cardiovascular risk. Nevertheless, its relationship with peripheral artery disease (PAD) remains ambiguous. Consequently, the present study aimed to explore the association between METS-VF and PAD. METHODS AND RESULTS: This prospective study was based on a Chinese H-type hypertension cohort, comprising 6,452 patients. The association between METS-VF and PAD was evaluated using the Cox proportional hazards regression analysis and the method of restricted cubic splines (RCS). During an median follow-up time of 3.9 years, 266 PAD events occurred. The mean age of all participants was 63.20 ± 8.38 years. In the fully adjusted model, each 1-unit increase of METS-VF raised the risk of PAD by 21.0% (HR = 1.21, 95%CI: 1.07, 1.37). There was a saturation effect of METS-VF with an inflection point of 8.63 on PAD. For METS-VF < 8.63, each unit increase was associated with a 69.0% higher risk of PAD (HR=1.69, 95%CI: 1.32-2.16), while for METS-VF ≥8.63, there was no significant association between them (HR=0.93, 95%CI: 0.73-1.19) (P for log-likelihood ratio test= 0.002). Subgroup analysis further showed a significant interaction between METS-VF and current smoking status (P for interaction<0.05), with a stronger association observed in non-smokers. CONCLUSION: METS-VF exhibited a saturation effect on PAD in hypertensive adults in China. Increased METS-VF was positively associated with a higher risk of PAD among hypertensive adults with METS-VF < 8.63, and this association was more pronounced in non-smokers.

Auteurs: Shiping Li, Congcong Yan, Meihui Wu, Tao Wang, Lingjuan Zhu, Chao Yu, Weifang Zhang, Wei Zhou, Huihui Bao, Xiaoshu Cheng

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Bron: Frontiers in endocrinology, https://doi.org/10.3389/fendo.2026.1764481. Bijgewerkt 2026-07-03T13:25:00Z. Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.