{"id":"875406113927","type":"article","url":"https://hartvaat.nl/2026/01/01/sophocarpine-beschermt-tegen-pulmonale-hypertensie-in-preklinische-modellen/","title":"Sophocarpine beschermt tegen pulmonale hypertensie in preklinische modellen","title_en":"Targeting Pulmonary Hypertension: Elucidating Sophocarpine's Protective Role via Preclinical Models.","category":"hypertensie","category_label":"Hypertensie","professions":["cardioloog"],"tags":["pulmonale-hypertensie"],"journal":"Mediators of inflammation","doi":"10.1155/mi/5524066","source_url":"https://doi.org/10.1155/mi/5524066","authors":["Feng Xie","Jie Feng","Kai Li","Yi Chen","Leilei Han","Yanqing Wu"],"significance":3,"published":"2026-01-01","source_date":"2026-01-01","image":"","kennis":["https://hartvaat.nl/kennis/hypertensie/eindorgaanschade-hypertensie/","https://hartvaat.nl/kennis/hypertensie/hypertensie-en-ckd/"],"congress":"","summary_en":"This study describes the protective role of sophocarpine, a plant alkaloid from Lindera aggregata, against pulmonary hypertension in preclinical models, identifying a potential novel therapeutic agent.","created":"2026-07-03T10:25:36Z","updated":"2026-07-03T13:25:00Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Pulmonale hypertensie manifesteert zich als verhoogde druk in de longslagaders en kan leiden tot hartfalen. Dit onderzoek beschrijft de beschermende rol van sophocarpine, een alkaloïde, in preklinische modellen van pulmonale hypertensie.","abstract_original":"BACKGROUND: Pulmonary hypertension (PH) is a serious disease that manifests itself as elevated pressure within the pulmonary arteries. The onset of PH is usually insidious, and if left untreated, it may lead to heart failure and even life-threatening conditions. Recent studies have shown that sophocarpine (SOP) has significant effects on antioxidant, anti-inflammatory, antifibrotic, and hemodynamic improvement, and it may become an emerging drug for the treatment of PH. However, the specific mechanism of action of SOP still requires further experimental validation. METHODS: We established in vivo and in vitro models of PH and treated them with varying concentrations of SOP. To visualize the changes in rats and cells, we used scratch assay, flow cytometry, Western blotting, pulmonary artery pressure measurement, biochemical analysis, enzyme-linked immunosorbent assay (ELISA), ultrasound scanning, hematoxylin and eosin (HE) staining, and Masson's trichrome staining. RESULTS: Our results showed that SOP significantly alleviated the inflammatory response and apoptosis induced by PH, reduced pulmonary artery pressure, and restored the balance of pulmonary artery remodeling. These effects were found to be effective in alleviating PH. CONCLUSION: Our study provides clear evidence that SOP has a significant protective effect in the PH model and is expected to be a promising therapeutic agent for PH."}