{"id":"f564e7f6d57c","type":"article","url":"https://hartvaat.nl/2026/01/05/grsf1-beschermt-tegen-hartfalen-door-bcaa-homeostase-te-handhaven/","title":"GRSF1 beschermt tegen hartfalen door BCAA-homeostase te handhaven","title_en":"GRSF1 Protects Against Heart Failure by Maintaining BCAA Homeostasis","category":"hartfalen","category_label":"Hartfalen","professions":["cardioloog"],"tags":[],"journal":"Circulation","doi":"https://www.ahajournals.org/doi/abs/10.1161/CIRCULATIONAHA.125.074700","source_url":"https://doi.org/https://www.ahajournals.org/doi/abs/10.1161/CIRCULATIONAHA.125.074700","authors":["Hu Wang"],"significance":6,"published":"2026-01-05","source_date":"2026-01-05","image":"","kennis":["https://hartvaat.nl/kennis/hartfalen/diagnose-hartfalen-stappenplan/"],"congress":"","summary_en":"This basic science study showed that GRSF1 protects against heart failure by maintaining branched-chain amino acid homeostasis, revealing a novel metabolic regulatory mechanism in cardiac disease.","created":"2026-07-03T10:25:35Z","updated":"2026-07-03T13:24:59Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Verstoringen in cardiaal vertaktketenamiozuurmetabolisme en mitochondriale homeostase zijn betrokken bij hartfalen. Dit onderzoek toont dat GRSF1 beschermt tegen hartfalen door de BCAA-homeostase te handhaven.","abstract_original":"BACKGROUND:Imbalances in cardiac branched-chain amino acid (BCAA) metabolism and mitochondrial homeostasis are implicated in the onset and development of heart failure. However, the mechanisms triggering the downregulation of cardiac BCAA metabolism in heart failure remain unclear. Here, we identify a novel role of the RNA-binding protein GRSF1 (guanine-rich RNA sequence binding factor 1) in post-transcriptionally regulating cell-intrinsic BCAA metabolic pathways, ultimately contributing to the pathogenesis of heart failure.METHODS:We examined GRSF1 expression in the heart tissues of patients with dilated cardiomyopathy and generated mice with cardiomyocyte-specific deletion or overexpression of GRSF1 in vivo to investigate its role in heart failure. The effect of GRSF1 on BCAA homeostasis was assessed through untargeted and targeted metabolomics and mitochondrial function analysis. To elucidate the mechanisms underlying GRSF1-mediated metabolic regulation, we employed mice with cardio"}