{"id":"ae7149789e42","type":"article","url":"https://hartvaat.nl/2026/01/05/samenstelling-en-classificatie-van-coronaire-atherosclerotische-plaques-bij-hype/","title":"Samenstelling en classificatie van coronaire atherosclerotische plaques bij hypercholesterolemische varkens","title_en":"Coronary atherosclerotic plaque composition and classification in hypercholesterolemic pigs","category":"cholesterol","category_label":"Cholesterol","professions":["cardioloog"],"tags":["acuut-coronair-syndroom","atherosclerose","cardiovasculaire-genetica","diabetes-type-1","dyslipidemie","ezetimibe","familiaire-hypercholesterolemie","familiaire-hypercholesterolemie-screening","laminopathie","ldl-cholesterol","pcsk9-remmers","plaquekarakterisatie","stabiel-coronairlijden","statines","vrouwen"],"journal":"Atherosclerosis","doi":"https://www.atherosclerosis-journal.com/article/S0021-9150(26)00001-8/fulltext","source_url":"https://doi.org/https://www.atherosclerosis-journal.com/article/S0021-9150(26)00001-8/fulltext","authors":["Mingqiao Li","Di Tian","Patrice Delafontaine","Sergiy Sukhanov"],"significance":4,"published":"2026-01-05","source_date":"2026-01-05","image":"","kennis":["https://hartvaat.nl/kennis/lipiden/genetisch-onderzoek-fh/"],"congress":"","summary_en":"This study characterised and classified coronary atherosclerotic plaque composition and progression in Rapacz pigs with familial hypercholesterolaemia, establishing a standardised classification system for this widely used preclinical atherosclerosis model.","created":"2026-07-03T10:25:35Z","updated":"2026-07-03T13:24:59Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Rapacz-varkens met familiaire hypercholesterolemie ontwikkelen atherosclerotische laesies die sterk lijken op humane coronaire atherosclerose. Dit onderzoek classificeert de plaquesamenstelling en -progressie in dit diermodel.","abstract_original":"Rapacz pigs with familial hypercholesterolemia (FH pigs) fed with high-fat diet (HFD) develop early atherosclerotic lesions and complex atheromas in coronaries mimicking human coronary atherosclerotic disease (CAD). FH pigs have proven to be an excellent model for basic and pre-clinical atherosclerosis-focused research. However, unlike human atherosclerosis there has been no established classification system for porcine atherosclerosis."}