# Afferente niersenuwen veroorzaken sympathische overactivatie en hypertensief hartfalen

*geplaatst 2026-01-07 · Hartfalen · Hypertension · doi https://www.ahajournals.org/doi/abs/10.1161/HYPERTENSIONAHA.125.25247 · https://hartvaat.nl/2026/01/07/afferente-niersenuwen-veroorzaken-sympathische-overactivatie-en-hypertensief-har/*

Sympathische activatie speelt een rol bij hartfalenontwikkeling. Afferente niersenuwinput kan sympathische overactivatie induceren via de hypothalame paraventriculaire nucleus. Deze studie onderzocht het mechanisme bij hypertensief hartfalen.

## English: Afferent Renal Nerves Drive Sympathoexcitation and Hypertensive Heart Failure

This study investigated how afferent renal nerves drive sympathoexcitation and contribute to hypertensive heart failure through the hypothalamic paraventricular nucleus. The findings support renal denervation strategies targeting afferent signalling pathways.

## Abstract (original, from the publication)

Hypertension, Volume 83, Issue 3, Page e25247, March 1, 2026. BACKGROUND:Sympathetic activation plays a role in heart failure (HF) development. Afferent renal nerve input may induce sympathoexcitation via the hypothalamic paraventricular nucleus (PVN), which projects to the rostral ventrolateral medulla, a center for sympathetic regulation. Central dendritic release of vasopressin from PVN neurons reportedly stimulates neighboring presympathetic neurons, causing sympathoexcitation. This study investigated whether afferent renal nerves contribute to hypertensive cardiac dysfunction and whether the afferent renal nerve-PVN axis mediates sympathoexcitation via central vasopressin using salt-loaded Dahl salt-sensitive rats, a model of hypertensive HF.METHODS:Salt loading began at 6 weeks of age, with selective afferent renal denervation and total renal denervation performed at 9 weeks in Dahl salt-sensitive rats. HF phenotypes were examined at 16 weeks, while sympathomodulation by afferent

Auteurs: Shota Ikeda

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Bron: Hypertension, https://doi.org/https://www.ahajournals.org/doi/abs/10.1161/HYPERTENSIONAHA.125.25247. Bijgewerkt 2026-07-03T18:38:17Z. Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.