{"id":"f38409e3a0b9","type":"article","url":"https://hartvaat.nl/2026/01/07/circulerend-malat1-bij-pre-eclampsie-en-cardiometabool-risico/","title":"Circulerend MALAT1 bij pre-eclampsie en cardiometabool risico","title_en":"Circulating MALAT1 in Preeclampsia and Association With Cardiometabolic Risk","category":"hypertensie","category_label":"Hypertensie","professions":["internist"],"tags":[],"journal":"Hypertension","doi":"https://www.ahajournals.org/doi/abs/10.1161/HYPERTENSIONAHA.125.26379","source_url":"https://doi.org/https://www.ahajournals.org/doi/abs/10.1161/HYPERTENSIONAHA.125.26379","authors":["Tove Lekva"],"significance":5,"published":"2026-01-07","source_date":"2026-01-07","image":"","kennis":["https://hartvaat.nl/kennis/nierziekte/nierziekte-en-cardiovasculair-risico/","https://hartvaat.nl/kennis/hypertensie/hypertensie-en-ckd/"],"congress":"","summary_en":"This study investigated the long noncoding RNA MALAT1 as a circulating biomarker in preeclampsia and its association with cardiometabolic risk. MALAT1 expression changes may link pregnancy-related hypertensive disorders to long-term cardiovascular disease risk.","created":"2026-07-03T10:25:35Z","updated":"2026-07-03T13:24:58Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Pre-eclampsie treft 2-8% van de zwangerschappen en verhoogt het latere cardiovasculaire risico. Het lange niet-coderende RNA MALAT1 werd onderzocht als circulerende biomarker bij pre-eclampsie en de associatie met cardiometabool risico.","abstract_original":"Hypertension, Volume 83, Issue 3, Page e26379, March 1, 2026. BACKGROUND:Preeclampsia is a hypertensive disorder affecting 2% to 8% of pregnancies. Women with a history of preeclampsia have an increased risk of cardiovascular disease. The long noncoding RNAMALAT1is shown to regulate inflammatory responses linked to cardiovascular disease.MALAT1is decreased in preeclampsia placentas and may have a cis-regulatory function on neighboring RNAs.METHODS:Expression ofMALAT1,NEAT1,mascRNA,SCYL1, andFRMD8was assessed in peripheral blood mononuclear cells, andMALAT1in plasma and extracellular vesicles, at 22 to 24 and 36 to 38 weeks of gestation in healthy (n=214) and preeclampsia (n=37) women from the STORK cohort study (STORe barn og Komplikasjoner, translated as Large Babies and Complications) and at 5-year follow-up in women with and without history of preeclampsia (n=29; n=271). We investigated their associations with established markers of disease activity and later cardiometabolic risk.MA"}