# CXCR6+ T-cellen veroorzaken immuuncheckpointremmer-myocarditis

*geplaatst 2026-01-07 · Algemeen · Circulation · doi https://www.ahajournals.org/doi/abs/10.1161/CIRCULATIONAHA.125.076976 · https://hartvaat.nl/2026/01/07/cxcr6-t-cellen-veroorzaken-immuuncheckpointremmer-myocarditis/*

Myocarditis is een ernstige complicatie van immuuncheckpointremmers, vooral bij combinatietherapie met relatlimab (anti-LAG-3). Dit onderzoek identificeert CXCR6+ T-cellen als drijvende kracht achter ICI-geïnduceerde myocarditis.

## English: CXCR6+ T Cells Drive Immune Checkpoint Inhibitor Myocarditis

This study identified CXCR6+ T cells as key drivers of immune checkpoint inhibitor-associated myocarditis, particularly with combination ICI therapy including anti-LAG-3 agents. The mechanistic insight may guide future prevention and treatment strategies for this serious complication.

## Abstract (original, from the publication)

BACKGROUND:Myocarditis is a severe complication of immune checkpoint inhibitors (ICIs). The major risk factor for ICI myocarditis is the use of combination ICI treatment, especially when relatlimab, a novel anti–LAG-3 (lymphocyte-activation gene 3) antibody, is combined with anti–PD-1 (programmed cell death protein 1) therapy. Although pathogenic T cells are necessary for ICI myocarditis, the specific signaling and T-cell populations that drive cardiac infiltration have not been fully elucidated, especially in setting of anti–LAG-3/PD-1 treatment.METHODS:We used VigiBase, an international pharmacovigilance database, to assess the risk of myocarditis with anti–LAG-3 compared with other ICI treatment regimens. We identified a mouse model of LAG-3/PD-1–associated ICI myocarditis through genetic deletion of immune checkpoints LAG-3 and PD-1 (Lag3-/-, Pdcd1-/-mice) and performed rigorous cardiac phenotyping using histology, flow cytometry, electrocardiography, single-cell RNA sequencing, an

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Bron: Circulation, https://doi.org/https://www.ahajournals.org/doi/abs/10.1161/CIRCULATIONAHA.125.076976. Bijgewerkt 2026-07-03T13:24:58Z. Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.