{"id":"44ddc1a2f6c9","type":"article","url":"https://hartvaat.nl/2026/01/07/serpinb1-beschermt-tegen-hypoxie-geinduceerde-pulmonale-hypertensie-via-macrofaa/","title":"SerpinB1 beschermt tegen hypoxie-geïnduceerde pulmonale hypertensie via macrofaag-PASMC-crosstalk","title_en":"Targeting Macrophage Crosstalk to PASMC by Blunting Inflammatory Phenotype Via SerpinB1 Protects Against Hypoxia-Induced Pulmonary Hypertension","category":"hypertensie","category_label":"Hypertensie","professions":["cardioloog"],"tags":["bloeddrukbehandeling","pulmonale-hypertensie"],"journal":"Hypertension","doi":"https://www.ahajournals.org/doi/abs/10.1161/HYPERTENSIONAHA.125.25832","source_url":"https://doi.org/https://www.ahajournals.org/doi/abs/10.1161/HYPERTENSIONAHA.125.25832","authors":["Jiajin Hao"],"significance":5,"published":"2026-01-07","source_date":"2026-01-07","image":"","kennis":[],"congress":"","summary_en":"This study demonstrates that SerpinB1 protects against hypoxia-induced pulmonary hypertension by blunting the inflammatory phenotype of perivascular macrophages, thereby reducing their pathological crosstalk with pulmonary artery smooth muscle cells.","created":"2026-07-03T10:25:34Z","updated":"2026-07-03T18:38:17Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Perivasculaire macrofagen spelen een significante rol bij hypoxie-geïnduceerde pulmonale hypertensie via crosstalk met gladde spiercellen. Dit onderzoek toont dat SerpinB1 het inflammatoire fenotype van macrofagen remt en zo beschermt.","abstract_original":"Hypertension, Volume 83, Issue 3, Page e25832, March 1, 2026. BACKGROUND:Perivascular macrophages play a significant role in the pathogenesis of hypoxia-induced pulmonary hypertension via crosstalk to pulmonary artery smooth muscle cells (PASMCs) to stimulate their proliferation and pulmonary vascular remodeling. However, whether hypoxia exposure of macrophages affects cellular crosstalk remains entirely unclear. This study aimed to decipher the effects of hypoxia on macrophages’ crosstalk to PASMCs and elucidate the underlying molecular mechanisms.METHODS:Conditioned medium obtained from bone marrow-derived macrophages under normoxia or hypoxia was transferred for hypoxic culture of primary mouse PASMCs, followed by RNA sequencing analysis. Myeloid-specific SerpinB1-overexpressing mice were generated to explore SerpinB1’s role in macrophage inflammatory phenotype, PASMC proliferation, and pulmonary vascular remodeling.RESULTS:Hypoxia-exposure of macrophages produced a conspicuous augm"}