{"id":"acdc1e725fd2","type":"article","url":"https://hartvaat.nl/2026/01/08/eindpuntgebaseerde-drempel-voor-de-ambulante-arteriele-stijfheidsindex/","title":"Eindpuntgebaseerde drempel voor de ambulante arteriële stijfheidsindex","title_en":"End Point–Based Threshold for the Ambulatory Arterial Stiffness Index","category":"hypertensie","category_label":"Hypertensie","professions":["cardioloog","internist"],"tags":["perifeer-vaatlijden"],"journal":"Hypertension","doi":"https://www.ahajournals.org/doi/abs/10.1161/HYPERTENSIONAHA.125.25442","source_url":"https://doi.org/https://www.ahajournals.org/doi/abs/10.1161/HYPERTENSIONAHA.125.25442","authors":[],"significance":6,"published":"2026-01-08","source_date":"2026-01-08","image":"","kennis":[],"congress":"","summary_en":"This individual participant data meta-analysis established an endpoint-based threshold for the ambulatory arterial stiffness index (AASI), providing a clinically actionable cutoff for this vascular biomarker.","created":"2026-07-03T10:25:34Z","updated":"2026-07-03T13:24:58Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"De ambulante arteriële stijfheidsindex (AASI) wordt steeds meer gebruikt in klinisch onderzoek. Deze individuele-deelnemer meta-analyse consolideert de prognostische waarde en stelt eindpuntgebaseerde drempelwaarden vast.","abstract_original":"Hypertension, Volume 83, Issue 3, Page e25442, March 1, 2026. BACKGROUND:The ambulatory arterial stiffness index (AASI) is increasingly used in clinical research and practice. This individual-participant meta-analysis aims to consolidate the prognostic accuracy of AASI in the general population and to derive an end point–based AASI risk threshold.METHODS:In 12 558 individuals enrolled in 14 population studies (48.8% women; mean age, 59.3 years), AASI was derived by regressing 24-hour diastolic on systolic blood pressure (mm Hg/mm Hg). Using Cox regression, the risk-carrying AASI threshold was established by examining stepwise increasing AASI levels and by determining the AASI level, yielding a 10-year risk similar to an office systolic pressure of 140 mm Hg.RESULTS:Over 10.7 years (median), 3027 all-cause deaths and 2183 cardiovascular end points occurred. In all participants, multivariable-adjusted hazard ratios expressing the all-cause deaths and cardiovascular end point risk per 1-S"}